Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	49368
Country	China

Received	2019-06-01 06:00
Peer-Review Started	2019-06-04 07:52
To Make the First Decision	2019-08-01 00:05
Return for Revision	2019-08-02 07:53
Revised	2019-08-05 12:36
Second Decision	2019-09-12 10:27
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2019-09-13 04:27
Articles in Press	2019-09-13 04:27
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-10-13 20:35
Typeset the Manuscript	2019-12-02 07:45
Publish the Manuscript Online	2019-12-31 07:02

ISSN	1948-5204 (online)
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Category	Genetics & Heredity
Manuscript Type	Basic Study
Article Title	Identification of candidate biomarkers correlated with pathogenesis of postoperative peritoneal adhesion by using microarray analysis
Manuscript Source	Unsolicited Manuscript
All Author List	Yao-Yao Bian, Li-Li Yang, Yan Yan, Min Zhao, Yan-Qi Chen, Ya-Qi Zhou, Zi-Xin Wang, Wen-Lin Li and Li Zeng
ORCID	Author(s) ORCID Number Yao-Yao Bian http://orcid.org/0000-0002-9968-2501 Li-Li Yang http://orcid.org/0000-0001-5220-3094 Yan Yan http://orcid.org/0000-0002-2702-3654 Min Zhao http://orcid.org/0000-0003-3691-1650 Yan-Qi Chen http://orcid.org/0000-0003-1532-1192 Ya-Qi Zhou http://orcid.org/0000-0003-4969-9126 Zi-Xin Wang http://orcid.org/0000-0002-1292-2454 Wen-Lin Li http://orcid.org/0000-0002-7105-2743 Li Zeng http://orcid.org/0000-0002-9095-9439
Funding Agency and Grant Number	Funding Agency Grant Number the National Natural Science Foundation of China 81704084 the National Natural Science Foundation of China 81603529 the National Natural Science Foundation of China 81673982 the Science and Technology Projects of Jiangsu Provincial Bureau of Traditional Chinese Medicine YB2017002 the Science and Technology Projects of Jiangsu Provincial Bureau of Traditional Chinese Medicine YB2015002 the Natural Science Foundation of the Jiangsu Higher Education Institutions 16KJB360002 the Postgraduate Research and Practice Innovation Program of Jiangsu Province KYCX18_1541 Qing Lan Project Chinese Medicine Advantage Discipline Funding Project and China Scholarship Council
Corresponding Author	Li Zeng, PhD, Academic Research, Professor, School of First Clinical Medicine and Jingwen Library, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210023, Jiangsu Province, China. zengli@njucm.edu.cn
Key Words	Postoperative peritoneal adhesion; Candidate biomarkers; Molecular pathogenesis; Bioinformatics analysis; ;
Core Tip	Postoperative peritoneal adhesion (PPA) remains an urgent clinical concern due to the increasing abdominal surgery. The occurrence and formation of adhesion come from a complex biological process. However, the molecular mechanisms on the basis of microarray data profile, followed by peritoneal adhesion formation, are largely unknown. In this study, we uncovered the underlying pathogenesis of PPA in molecular levels using bioinformatics analysis methods. The results were further validated using animal experiment. It showed that regulatory evidences chain of TLR4/MyD88/NF-κB/inflammatory cytokines/peritoneal adhesion played key roles in the pathogenesis of postoperative adhesion. Our findings may provide new cues of peritoneal adhesion formation.
Publish Date	2019-12-31 07:02
Citation	Bian YY, Yang LL, Yan Y, Zhao M, Chen YQ, Zhou YQ, Wang ZX, Li WL, Zeng L. Identification of candidate biomarkers correlated with pathogenesis of postoperative peritoneal adhesion by using microarray analysis. World J Gastrointest Oncol 2020; 12(1): 54-65
URL	https://www.wjgnet.com/1948-5204/full/v12/i1/54.htm
DOI	https://dx.doi.org/10.4251/wjgo.v12.i1.54

Full Article (PDF)	WJGO-12-54.pdf
Full Article (Word)	WJGO-12-54.docx
Manuscript File	FP7024_ce36_CE1MS_edit2.docx
Answering Reviewers	49368-Answering reviewers.pdf
Audio Core Tip	49368-Audio core tip.mp3
Biostatistics Review Certificate	49368-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	49368-Conflict-of-interest statement.pdf
Copyright License Agreement	49368-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	49368-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	49368-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	49368-Language certificate.pdf
Peer-review Report	49368-Peer-review(s).pdf
Scientific Misconduct Check	49368-Scientific misconduct check.pdf
Scientific Editor Work List	49368-Scientific editor work list.pdf
CrossCheck Report	49368-CrossCheck report.pdf