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Articles Published Processes
10/28/2019 11:23:12 AM | Browse: 809 | Download: 1953
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Received |
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2019-07-13 03:27 |
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Peer-Review Started |
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2019-07-16 00:31 |
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To Make the First Decision |
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2019-08-19 00:53 |
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Return for Revision |
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2019-08-21 04:18 |
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Revised |
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2019-09-03 13:30 |
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Second Decision |
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2019-09-20 09:07 |
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Accepted by Journal Editor-in-Chief |
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2019-09-21 14:16 |
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Accepted by Executive Editor-in-Chief |
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2019-09-28 04:48 |
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Articles in Press |
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2019-09-28 04:48 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-10-05 08:18 |
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Typeset the Manuscript |
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2019-10-25 09:28 |
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Publish the Manuscript Online |
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2019-10-28 11:23 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Insulin-like growth factor 2 mRNA-binding protein 1 promotes cell proliferation via activation of AKT and is directly targeted by microRNA-494 in pancreatic cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Bai-Shun Wan, Ming Cheng and Ling Zhang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ling Zhang, MD, Professor, Department of Hepatobiliary and Pancreatic Surgery, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, No.127 Dongming Road, Zhengzhou 450008, Henan Province, China. zzuzhangling@163.com |
| Key Words |
Pancreatic cancer; Insulin-like growth factor 2 mRNA-binding protein 1; Proliferation; MicroRNA-494; ; |
| Core Tip |
Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) exerts vital roles in the development of various cancers; however, the expression, functional role and regulatory mechanisms of IGF2BP1 in pancreatic cancer remain unclear. In this study, the expression levels of IGF2BP1 and miR-494 were mined in Gene Expression Omnibus datasets and validated in both clinical samples and cell lines. The relationship of IGF2BP1 expression and clinicopathological factors of pancreatic cancer patients was analyzed. The effect of IGF2BP1 on pancreatic cancer cell proliferation and underlying regulatory mechanism were investigated. Our study suggests that IGF2BP1 may be a new therapeutic target of pancreatic cancer. |
| Publish Date |
2019-10-28 11:23 |
| Citation |
Wan BS, Cheng M, Zhang L. Insulin-like growth factor 2 mRNA-binding protein 1 promotes cell proliferation via activation of AKT and is directly targeted by microRNA-494 in pancreatic cancer. World J Gastroenterol 2019; 25(40): 6063-6076 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i40/6063.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i40.6063 |
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