Publication Name	World Journal of Gastroenterology
Manuscript ID	50263
Country	China

Received	2019-07-13 03:27
Peer-Review Started	2019-07-16 00:31
To Make the First Decision	2019-08-19 00:53
Return for Revision	2019-08-21 04:18
Revised	2019-09-03 13:30
Second Decision	2019-09-20 09:07
Accepted by Journal Editor-in-Chief	2019-09-21 14:16
Accepted by Company Editor-in-Chief	2019-09-28 04:48
Articles in Press	2019-09-28 04:48
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-10-05 08:18
Typeset the Manuscript	2019-10-25 09:28
Publish the Manuscript Online	2019-10-28 11:23

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Insulin-like growth factor 2 mRNA-binding protein 1 promotes cell proliferation via activation of AKT and is directly targeted by microRNA-494 in pancreatic cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Bai-Shun Wan, Ming Cheng and Ling Zhang
ORCID	Author(s) ORCID Number Bai-Shun Wan http://orcid.org/0000-0002-0590-3896 Ming Cheng http://orcid.org/0000-0001-5220-963X Ling Zhang http://orcid.org/0000-0001-7219-4252
Funding Agency and Grant Number
Corresponding Author	Ling Zhang, MD, Professor, Department of Hepatobiliary and Pancreatic Surgery, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, No.127 Dongming Road, Zhengzhou 450008, Henan, China. zzuzhangling@163.com
Key Words	Pancreatic cancer; Insulin-like growth factor 2 mRNA-binding protein 1; Proliferation; MicroRNA-494; ;
Core Tip	Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) exerts vital roles in the development of various cancers; however, the expression, functional role and regulatory mechanisms of IGF2BP1 in pancreatic cancer remain unclear. In this study, the expression levels of IGF2BP1 and miR-494 were mined in Gene Expression Omnibus datasets and validated in both clinical samples and cell lines. The relationship of IGF2BP1 expression and clinicopathological factors of pancreatic cancer patients was analyzed. The effect of IGF2BP1 on pancreatic cancer cell proliferation and underlying regulatory mechanism were investigated. Our study suggests that IGF2BP1 may be a new therapeutic target of pancreatic cancer.
Publish Date	2019-10-28 11:23
Citation	Wan BS, Cheng M, Zhang L. Insulin-like growth factor 2 mRNA-binding protein 1 promotes cell proliferation via activation of AKT and is directly targeted by microRNA-494 in pancreatic cancer. World J Gastroenterol 2019; 25(40): 6063-6076
URL	https://www.wjgnet.com/1007-9327/full/v25/i40/6063.htm
DOI	https://dx.doi.org/10.3748/wjg.v25.i40.6063

Full Article (PDF)	WJG-25-6063.pdf
Full Article (Word)	WJG-25-6063.docx
The ARRIVE Guidelines	50263-The-ARRIVE-Guidelines-revision.pdf
Manuscript File	50263-Review_Edited.docx
Answering Reviewers	50263-Answering reviewers.pdf
Audio Core Tip	50263-Audio core tip.mp3
Biostatistics Review Certificate	50263-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	50263-Conflict-of-interest statement.pdf
Copyright License Agreement	50263-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	50263-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	50263-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	50263-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	50263-Language certificate.pdf
Supplementary Material	50263-Supplementary material.pdf
Peer-review Report	50263-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	50263-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	50263-Bing-Tang JZ-2.png
Scientific Misconduct Check	50263-Scientific misconduct check.pdf
Scientific Editor Work List	50263-Scientific editor work list.pdf