| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Case Report |
| Article Title |
Six families with balanced chromosome translocation associated with reproductive risks in Hainan Province: A case report and review of literature
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yun-Chun Chen, Xu-Ning Huang, Chang-Ying Kong and Jian-Dong Hu |
| ORCID |
|
| Funding Agency and Grant Number |
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| Corresponding Author |
Jian-Dong Hu, MD, Doctor, Doctor, Department of Internal Medicine, Haikou branch of Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine (Haikou Hospital of Traditional Chinese Medicine), No. 45 Jinpan Road, Haikou 570216, Hainan Province, China. hamlethu@163.com |
| Key Words |
Reproductive risk; Balanced translocation; Abnormal pregnancy; Genetic counseling; Case report; |
| Core Tip |
As the genetic substance with balanced translocation in individuals does not change which is usually characterized by normal phenotype. Case 1: 46, XY, t (3; 12) (q27; q24.1), infertility 3 years; Case 2: 46, XX, t (4; 16) (q31; q12), small uterus and irregular menstruation; Case 3: 46, XY, t (4; 5) (q33; q13), 9qh+, infertility; Case 4: 46, XX, t (11; 17) (q13; p11.2), 2 times of spontaneous abortion; Case 5: 46, XX, t (10; 13) (q24; q21.2), arrested fetal development for 1 time; Case 6: 46, XX, t (1; 4) (p36.1; q31.1), arrested fetal development for 2 times. This study suggested that balanced chromosomal translocation carriers are associated with reproductive risks. The first 4 reported chromosomal aberration karyotypes provided an important basis for studying the occurrence of genetic diseases. |
| Publish Date |
2020-01-07 01:54 |
| Citation |
Chen YC, Huang XN, Kong CY, Hu JD. Six families with balanced chromosome translocation associated with reproductive risks in Hainan Province: A case report and review of literature. World J Clin Cases 2020;8(1): 222-233 |
| URL |
https://www.wjgnet.com/2307-8960/full/v8/i1/222.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v8.i1.222 |
