Publication Name	World Journal of Critical Care Medicine
Manuscript ID	51981
Country	India

Received	2019-10-11 11:38
Peer-Review Started	2019-10-11 11:38
To Make the First Decision	2019-11-04 00:32
Return for Revision	2019-11-05 00:24
Revised	2019-12-23 15:06
Second Decision	2020-01-13 10:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2020-01-13 21:39
Articles in Press	2020-01-13 21:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-01-16 09:05
Publish the Manuscript Online	2020-02-10 07:36

ISSN	2220-3141(online)
Open Access
Copyright	© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Critical Care Medicine
Manuscript Type	Observational Study
Article Title	Experience with hemoadsorption (CytoSorb<sup>®</sup>) in the management of septic shock patients
Manuscript Source	Unsolicited Manuscript
All Author List	Yatin Mehta, Chitra Mehta, Ashish Kumar, Joby V George, Aditi Gupta, Saurabh Nanda, Gaurav Kochhar and Arun Raizada
ORCID	Author(s) ORCID Number Yatin Mehta http://orcid.org/0000-0003-2492-6687 Chitra Mehta http://orcid.org/0000-0002-6738-1042 Ashish Kumar http://orcid.org/0000-0001-9809-3513 Joby V George http://orcid.org/0000-0002-7637-8929 Aditi Gupta http://orcid.org/0000-0001-9713-4993 Saurabh Nanda http://orcid.org/0000-0002-1462-4901 Gaurav Kochhar http://orcid.org/0000-0001-6151-3684 Arun Raizada http://orcid.org/0000-0002-3058-4014
Funding Agency and Grant Number
Corresponding Author	Yatin Mehta, FRCA, MD, MNAMS, Doctor, Doctor, Institute of Critical care and Anesthesia, Medanta The Medicity, Sector 38, Gurgaon 122006, Haryana, India. yatin.mehtacriticalcare@gmail.com
Key Words	Hemoadsorption; Sepsis; Cytokines; Clinical conditions; Inflammation and extracorporeal;
Core Tip	CytoSorb® is a promising new extracorporeal cytokine hemoadsorption device that can modulate the cytokine storm during sepsis. This retrospective study evaluated clinical outcomes after CytoSorb® therapy of 100 patients admitted to intensive care unit with sepsis. We observed a significant reduction in vasopressors dosage in 40 patients who survived. The survivors also had a reduction in all the biomarker levels (procalcitonin, C-reactive protein, serum lactate and bilirubin) and inflammatory markers (interleukin 6, interleukin 10 and tumour necrosis factor) after CytoSorb® therapy. Notably, 28% of patients who were given CytoSorb® therapy < 48 h after onset of septic shock survived.
Publish Date	2020-02-10 07:36
Citation	Mehta Y, Mehta C, Kumar A, George JV, Gupta A, Nanda S, Kochhar G, Raizada A. Experience with hemoadsorption (CytoSorb®) in the management of septic shock patients. World J Crit Care Med 2020; 9(1): 1-12
URL	https://www.wjgnet.com/2220-3141/full/v9/i1/1.htm
DOI	https://dx.doi.org/10.5492/wjccm.v9.i1.1

Full Article (PDF)	WJCCM-9-1.pdf
Full Article (Word)	WJCCM-9-1.docx
Manuscript File	51981-Review.doc
Answering Reviewers	50603-Answering reviewers.pdf
Audio Core Tip	50603-Audio core tip.mp3
Biostatistics Review Certificate	50603-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	51981-Conflict-of-interest statement.pdf
Copyright License Agreement	51981-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	51981-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	51981-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	51981-Language certificate.pdf
Supplementary Material	51981-Supplementary material.docx
Peer-review Report	50603-Peer-review(s).pdf
Scientific Misconduct Check	51981-Scientific misconduct check.pdf
Scientific Editor Work List	50603-Scientific editor work list.pdf
CrossCheck Report	51981-CrossCheck report.pdf