Publication Name	World Journal of Critical Care Medicine
Manuscript ID	51981
Country	India

Received	2019-10-11 11:38
Peer-Review Started	2019-10-11 11:38
To Make the First Decision	2019-11-04 00:32
Return for Revision	2019-11-05 00:24
Revised	2019-12-23 15:06
Second Decision	2020-01-13 10:41
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-01-13 21:39
Articles in Press	2020-01-13 21:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-01-16 09:05
Publish the Manuscript Online	2020-02-10 07:36

ISSN	2220-3141(online)
Open Access
Copyright	© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Critical Care Medicine
Manuscript Type	Observational Study
Article Title	Experience with hemoadsorption (CytoSorb<sup>®</sup>) in the management of septic shock patients
Manuscript Source	Unsolicited Manuscript
All Author List	Yatin Mehta, Chitra Mehta, Ashish Kumar, Joby V George, Aditi Gupta, Saurabh Nanda, Gaurav Kochhar and Arun Raizada
ORCID	Author(s) ORCID Number Yatin Mehta http://orcid.org/0000-0003-2492-6687 Chitra Mehta http://orcid.org/0000-0002-6738-1042 Ashish Kumar http://orcid.org/0000-0001-9809-3513 Joby V George http://orcid.org/0000-0002-7637-8929 Aditi Gupta http://orcid.org/0000-0001-9713-4993 Saurabh Nanda http://orcid.org/0000-0002-1462-4901 Gaurav Kochhar http://orcid.org/0000-0001-6151-3684 Arun Raizada http://orcid.org/0000-0002-3058-4014
Funding Agency and Grant Number
Corresponding Author	Yatin Mehta, FRCA, MD, MNAMS, Doctor, Institute of Critical care and Anesthesia, Medanta The Medicity, Sector 38, Gurgaon 122006, Haryana, India. yatin.mehtacriticalcare@gmail.com
Key Words	Hemoadsorption; Sepsis; Cytokines; Clinical conditions; Inflammation and extracorporeal;
Core Tip	CytoSorb® is a promising new extracorporeal cytokine hemoadsorption device that can modulate the cytokine storm during sepsis. This retrospective study evaluated clinical outcomes after CytoSorb® therapy of 100 patients admitted to intensive care unit with sepsis. We observed a significant reduction in vasopressors dosage in 40 patients who survived. The survivors also had a reduction in all the biomarker levels (procalcitonin, C-reactive protein, serum lactate and bilirubin) and inflammatory markers (interleukin 6, interleukin 10 and tumour necrosis factor) after CytoSorb® therapy. Notably, 28% of patients who were given CytoSorb® therapy < 48 h after onset of septic shock survived.
Publish Date	2020-02-10 07:36
Citation	Mehta Y, Mehta C, Kumar A, George JV, Gupta A, Nanda S, Kochhar G, Raizada A. Experience with hemoadsorption (CytoSorb®) in the management of septic shock patients. World J Crit Care Med 2020; 9(1): 1-12
URL	https://www.wjgnet.com/2220-3141/full/v9/i1/1.htm
DOI	https://dx.doi.org/10.5492/wjccm.v9.i1.1

Full Article (PDF)	WJCCM-9-1.pdf
Full Article (Word)	WJCCM-9-1.docx
Manuscript File	51981-Review.doc
Answering Reviewers	50603-Answering reviewers.pdf
Audio Core Tip	50603-Audio core tip.mp3
Biostatistics Review Certificate	50603-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	51981-Conflict-of-interest statement.pdf
Copyright License Agreement	51981-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	51981-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	51981-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	51981-Language certificate.pdf
Supplementary Material	51981-Supplementary material.docx
Peer-review Report	50603-Peer-review(s).pdf
Scientific Misconduct Check	51981-Scientific misconduct check.pdf
Scientific Editor Work List	50603-Scientific editor work list.pdf