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Articles Published Processes
3/16/2020 11:58:14 PM | Browse: 693 | Download: 770
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Received |
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2019-10-22 12:54 |
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Peer-Review Started |
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2019-10-22 12:55 |
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To Make the First Decision |
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2019-12-02 07:13 |
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Return for Revision |
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2019-12-04 01:42 |
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Revised |
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2020-01-31 18:04 |
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Second Decision |
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2020-02-09 06:31 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2020-02-11 18:34 |
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Articles in Press |
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2020-02-11 18:34 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-03-13 08:30 |
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Publish the Manuscript Online |
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2020-03-16 23:58 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
Glycoconjugation: An approach to cancer therapeutics
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Maria I Molejon, Gisela Weiz, Javier D Breccia and Maria Ines Vaccaro |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| ANPCyT |
PICT2016-1032 |
| Universidad de Buenos Aires |
UBACyT 2018 |
| ANPCyT |
PICT2018-02032 |
| ANPCyT |
PICT2017- 2070 |
| Universidad Nacional de La Pampa |
P.I. Q109 |
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| Corresponding Author |
Maria Ines Vaccaro, AGAF, PhD, Doctor, Professor, Department of Physiopathology, University of Buenos Aires, Junín 954, Ciudad de Buenos Aires C1113AAD, Argentina. mvaccaro@ffyb.uba.ar |
| Key Words |
Glycosylation; Gastrointestinal cancers; Antitumoral agents; Therapeutic strategies; Drug targeting; |
| Core Tip |
In nature, glycosylation is an effective strategy to expand the biological information of biomolecules by adding a new level of structural diversity. The high specificity of the interaction with carbohydrates and the overexpression of receptors available in tumoral cells to which can be specifically targeted by glycodrugs, allow selective administration of them to the tumoral tissues. It has been shown that glycosylation of antitumoral agents has improved pharmacokinetics parameters, reduced side effects, expanded half-life, and also reduced the doses of the glycodrugs. |
| Publish Date |
2020-03-16 23:58 |
| Citation |
Molejon MI, Weiz G, Breccia JD, Vaccaro MI. Glycoconjugation: An approach to cancer therapeutics. World J Clin Oncol 2020; 11(3): 110-120 |
| URL |
https://www.wjgnet.com/2218-4333/full/v11/i3/110.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v11.i3.110 |
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