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Articles Published Processes
2/27/2020 7:06:19 AM | Browse: 951 | Download: 1777
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Received |
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2019-10-22 03:54 |
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Peer-Review Started |
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2019-10-22 03:56 |
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To Make the First Decision |
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Return for Revision |
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2019-11-18 19:11 |
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Revised |
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2019-12-27 07:53 |
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Second Decision |
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2020-01-18 07:30 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-01-20 03:28 |
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Articles in Press |
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2020-01-20 03:28 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-02-25 01:54 |
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Publish the Manuscript Online |
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2020-02-27 07:06 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Rehabilitation |
| Manuscript Type |
Basic Study |
| Article Title |
C-C chemokine receptor type 2-overexpressing exosomes alleviated experimental post-stroke cognitive impairment by enhancing microglia/macrophage M2 polarization
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Huai-Chun Yang, Min Zhang, Rui Wu, Hai-Qing Zheng, Li-Ying Zhang, Jing Luo, Li-Li Li and Xi-Quan Hu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81871847 |
| National Natural Science Foundation of China |
81672261 |
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| Corresponding Author |
Xi-Quan Hu, MD, PhD, Chief Physician, Professor, Department of Rehabilitation Medicine, the Third Affiliated Hospital, Sun Yat-sen University, No. 600 Tianhe road, Guangzhou 510000, Guangdong Province, China. sysu_hu@163.com |
| Key Words |
Cognitive impairment; Stroke; Exosomes; C-C chemokine receptor type 2; Microglia/macrophage polarization; Remyelination |
| Core Tip |
Exosomes have been reported to possess the therapeutic benefit comparable to the therapeutic effects of mesenchymal stromal cells. However, the effects of exosomes derived from human umbilical cord mesenchymal stem cells (ExoCtrl) on post-stroke cognitive impairment (PSCI) have rarely been reported. Moreover, whether exosomes derived from C-C chemokine receptor type 2 (CCR2)-overexpressing human umbilical cord mesenchymal stem cells (ExoCCR2) have better therapeutic effects on PSCI and the possible mechanisms underlying these effects remained unclear. This study provides new insights into the use of genetically modified exosomes for PSCI treatment, offering new ideas for the clinical application of exosome-based therapies for PSCI. |
| Publish Date |
2020-02-27 07:06 |
| Citation |
Yang HC, Zhang M, Wu R, Zheng HQ, Zhang LY, Luo J, Li LL, Hu XQ. C-C chemokine receptor type 2-overexpressing exosomes alleviated experimental post-stroke cognitive impairment by enhancing microglia/macrophage M2 polarization. World J Stem Cells 2020; 12(2): 152-167 |
| URL |
https://www.wjgnet.com/1948-0210/full/v12/i2/152.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v12.i2.152 |
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