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Articles Published Processes
4/22/2020 1:22:08 PM | Browse: 730 | Download: 588
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Received |
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2019-10-26 17:03 |
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Peer-Review Started |
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2019-10-26 17:03 |
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To Make the First Decision |
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Return for Revision |
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2019-11-19 20:47 |
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Revised |
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2020-01-18 00:26 |
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Second Decision |
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2020-03-13 07:26 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2020-03-15 00:02 |
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Articles in Press |
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2020-03-15 00:02 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-04-13 10:20 |
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Publish the Manuscript Online |
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2020-04-22 13:22 |
| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Review |
| Article Title |
Do age-associated changes of voltage-gated sodium channel isoforms expressed in the mammalian heart predispose the elderly to atrial fibrillation?
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Emmanuel Isaac, Stephanie M Cooper, Sandra A Jones and Mahmoud Loubani |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Mahmoud Loubani, BM BCh, FRCS, MD, Consultant Cardiac Surgeon, Professor, Surgeon, Department of Cardiothoracic Surgery, Hull University Teaching Hospitals, Castle Road, Cottingham HU16 5JQ, United Kingdom. mahmoud.loubani@hey.nhs.uk |
| Key Words |
Voltage-gated; Sodium channels; Ageing; Atrial fibrillation; Nav 1.5; Nav 1.8 |
| Core Tip |
Nav1.8 has been implicated by multiple studies in producing the late sodium current, predisposing the cardiomyocyte to arrhythmogenic activity. Animal models have demonstrated an enhancement of this aberrant current in aged hearts. Human studies have identified a reduction of Nav1.5 and an increase in Nav1.8 in both heart failure and left ventricular hypertrophy, strongly suggesting that voltage-gated sodium channel expression plays a central role in the development of arrhythmia. Clinically, sodium channel blockade through Ranolazine has proved promising in terminating the arrhythmia. Prevention of atrial fibrillation should focus on lifestyle management, as well as targeting cardiac risk factors. Irbesartan has been demonstrated to slow atrial remodelling, prevent atrial fibrillation in animal models, as well as avert the arrhythmia in human subjects. |
| Publish Date |
2020-04-22 13:22 |
| Citation |
Isaac E, Cooper SM, Jones SA, Loubani M. Do age-associated changes of voltage-gated sodium channel isoforms expressed in the mammalian heart predispose the elderly to atrial fibrillation? World J Cardiol 2020; 12(4): 123-135 |
| URL |
https://www.wjgnet.com/1949-8462/full/v12/i4/123.htm |
| DOI |
https://dx.doi.org/10.4330/wjc.v12.i4.123 |
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