Publication Name	World Journal of Clinical Cases
Manuscript ID	53398
Country	China

Received	2020-02-24 10:15
Peer-Review Started	2020-02-24 10:15
To Make the First Decision
Return for Revision	2020-04-01 05:31
Revised	2020-04-01 08:51
Second Decision	2020-06-01 09:18
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-06-02 06:34
Articles in Press	2020-06-02 06:34
Publication Fee Transferred
Edit the Manuscript by Language Editor	2020-06-08 04:22
Typeset the Manuscript	2020-06-19 06:35
Publish the Manuscript Online	2020-06-24 07:33

ISSN	2307-8960 (online)
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Observational Study
Article Title	Real-time three-dimensional echocardiography predicts cardiotoxicity induced by postoperative chemotherapy in breast cancer patients
Manuscript Source	Unsolicited Manuscript
All Author List	Fang Zhou, Lin Niu, Min Zhao, Wei-Xing Ni and Jian Liu
ORCID	Author(s) ORCID Number Fang Zhou http://orcid.org/0000-0001-5581-2469 Lin Niu http://orcid.org/0000-0002-1442-6497 Min Zhao http://orcid.org/0000-0002-7308-102X Wei-Xing Ni http://orcid.org/0000-0002-2987-1622 Jian Liu http://orcid.org/0000-0001-7689-8193
Funding Agency and Grant Number	Funding Agency Grant Number Medical and Health Foundation Project of Zhejiang Province, China 2020KY690 Natural Science Foundation of Zhejiang Province LGF20H020004
Corresponding Author	Min Zhao, MD, Department of Ultrasound, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, No. 261 Huansha Road, Hangzhou 310006, Zhejiang Province, China. hzzhaomin@126.com
Key Words	Atrial volume; Chemotherapy; Breast cancer; Cardiac toxicity; Real-time three-dimensional echocardiography; Anthracyclines
Core Tip	Although chemotherapeutics can improve the curative effect of breast cancer, there is a certain degree of cardiotoxicity. The patient's cardiac function needs to be closely monitored during chemotherapy. Studies have found that left ventricular diastolic dysfunction can indicate early cardiac impairment. Therefore, the analysis of left ventricular diastolic function to evaluate the cardiac toxicity is the research focus. However, the current indicators can only prove that they are related to cardiotoxicity, but they cannot early predict the occurrence of cardiotoxicity. In this study, RT3DE was used to measure the left atrial volume, and it was found that the left atrial volume index was the most accurate in predicting the cardiotoxicity caused by chemotherapy in the early stage.
Publish Date	2020-06-24 07:33
Citation	Zhou F, Niu L, Zhao M, Ni WX, Liu J. Real-time three-dimensional echocardiography predicts cardiotoxicity induced by postoperative chemotherapy in breast cancer patients. World J Clin Cases 2020; 8(12): 2542-2553
URL	https://www.wjgnet.com/2307-8960/full/v8/i12/2542.htm
DOI	https://dx.doi.org/10.12998/wjcc.v8.i12.2542

Full Article (PDF)	WJCC-8-2542.pdf
Full Article (Word)	WJCC-8-2542.docx
Manuscript File	53398-Review_WangTQ.docx
Answering Reviewers	53398-Answering reviewers.pdf
Audio Core Tip	53398-Audio core tip.m4a
Biostatistics Review Certificate	53398-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	53398-Conflict-of-interest statement.pdf
Copyright License Agreement	53398-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	53398-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	53398-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	53398-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	53398-Language certificate.pdf
Peer-review Report	53398-Peer-review(s).pdf
Scientific Misconduct Check	53398-Scientific misconduct check.pdf
Scientific Editor Work List	53398-Scientific editor work list.pdf