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Articles Published Processes
5/29/2020 4:26:07 AM | Browse: 876 | Download: 869
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Received |
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2019-12-31 17:28 |
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Peer-Review Started |
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2019-12-31 17:29 |
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To Make the First Decision |
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Return for Revision |
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2020-03-27 01:57 |
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Revised |
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2020-04-07 16:40 |
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Second Decision |
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2020-04-29 12:36 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2020-05-05 15:21 |
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Articles in Press |
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2020-05-05 15:21 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-05-21 11:18 |
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Publish the Manuscript Online |
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2020-05-29 04:26 |
| ISSN |
2220-3230 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Links between donor macrosteatosis, interleukin-33 and complement after liver transplantation
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Kelley Núñez, Mohammad Hamed, Daniel Fort, David Bruce, Paul Thevenot and Ari Cohen |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ari Cohen, MD, Professor, Surgeon, Multi-Organ Transplant, Ochsner Clinic Foundation, 1514 Jefferson Hwy, New Orleans, LA 70121, United States. acohen@ochsner.org |
| Key Words |
Liver transplantation; Interleukin-33; Donor macrosteatosis; Complement; Early allograft dysfunction; Reperfusion |
| Core Tip |
As nonalcoholic fatty liver disease incidence continues to rise, steatosis, both micro- and macro- will continue to infiltrate the donor pool. While many transplant centers have success utilizing these extended criteria donor grafts, macrosteatotic grafts remain at increased risk. In this study, elevations in interleukin-33 and activated complement (C3a and C5a) in recipients immediately following reperfusion indicate that patients receiving macrosteatotic grafts may have more injury post-transplant. Through mRNA expression of donor biopsies, we identify potential target genes present in macrosteatotic grafts that could aid in deciphering which macrosteatotic grafts are safe for implantation. |
| Publish Date |
2020-05-29 04:26 |
| Citation |
Núñez K, Hamed M, Fort D, Bruce D, Thevenot P, Cohen A. Links between donor macrosteatosis, interleukin-33 and complement after liver transplantation. World J Transplant 2020; 10(5): 117-128 |
| URL |
https://www.wjgnet.com/2220-3230/full/v10/i5/117.htm |
| DOI |
https://dx.doi.org/ 10.5500/wjt.v10.i5.117 |
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