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5/14/2020 3:43:04 AM | Browse: 1405 | Download: 2821
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Received |
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2020-02-04 11:46 |
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Peer-Review Started |
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2020-02-04 11:46 |
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First Decision by Editorial Office Director |
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2020-03-21 23:09 |
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Return for Revision |
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2020-03-21 23:09 |
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Revised |
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2020-04-03 09:07 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2020-04-28 09:55 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2020-04-28 23:43 |
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Articles in Press |
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2020-04-28 23:43 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-05-13 01:26 |
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Publish the Manuscript Online |
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2020-05-14 03:43 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Genetic association analysis of CLEC5A and CLEC7A gene single-nucleotide polymorphisms and Crohn’s disease
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Nagi Elleisy, Sarah Rohde, Astrid Huth, Nicole Gittel, Änne Glass, Steffen Möller, Georg Lamprecht, Holger Schäffler and Robert Jaster |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Damp-Foundation |
2016-04 |
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| Corresponding Author |
Robert Jaster, MD, Academic Research, Professor, Senior Postdoctoral Fellow, Senior Scientist, Department of Medicine II, Division of Gastroenterology, Rostock University Medical Center, E.-Heydemann-Str. 6, Rostock 18057, Germany. robert.jaster@med.uni-rostock.de |
| Key Words |
Crohn’s disease; Single nucleotide polymorphisms; NOD2; CLEC5A; Gene expression; CXCL5 |
| Core Tip |
The genetic traits of Crohn’s disease (CD) are incompletely understood. Here, we report a potential association of single nucleotide polymorphism (SNP) rs1285933 in CLEC5A, a member of the C-type lectin domain family of pattern recognition receptors, with CD. Variants of SNP rs1285933 had no impact on CLEC5A gene expression in peripheral blood mononuclear cells but correlated with the expression of CXCL5. The SNPs rs2078178 and rs16910631 in CLEC7A were not associated with the disease. The role of CLEC5A in the pathophysiology of CD deserves further attention. |
| Publish Date |
2020-05-14 03:43 |
| Citation |
Elleisy N, Rohde S, Huth A, Gittel N, Glass Ä, Möller S, Lamprecht G, Schäffler H, Jaster R. Genetic association analysis of CLEC5A and CLEC7A gene single-nucleotide polymorphisms and Crohn’s disease. World J Gastroenterol 2020; 26(18): 2194-2202
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| URL |
https://www.wjgnet.com/1007-9327/full/v26/i18/2194.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i18.2194 |
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