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Articles Published Processes
9/22/2020 6:23:06 AM | Browse: 715 | Download: 1382
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Received |
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2020-03-25 20:52 |
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Peer-Review Started |
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2020-03-25 20:56 |
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To Make the First Decision |
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Return for Revision |
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2020-04-29 21:53 |
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Revised |
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2020-05-25 11:03 |
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Second Decision |
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2020-06-02 08:32 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-06-02 18:24 |
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Articles in Press |
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2020-06-02 18:24 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-06-11 01:15 |
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Typeset the Manuscript |
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2020-08-23 13:04 |
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Publish the Manuscript Online |
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2020-09-22 06:23 |
ISSN |
1948-0210 (online) |
Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Orthopedics |
Manuscript Type |
Review |
Article Title |
Mechanisms of action of neuropeptide Y on stem cells and its potential applications in orthopaedic disorders
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Manuscript Source |
Invited Manuscript |
All Author List |
Jian-Qun Wu, Nan Jiang and Bin Yu |
ORCID |
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Funding Agency and Grant Number |
Funding Agency |
Grant Number |
National Natural Science Foundation of China |
81830079 |
Guangzhou Health Science and Technology Project |
20191A011116 |
Science and Technology Project of Guangzhou Huadu District |
18-HDWS-003 |
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Corresponding Author |
Bin Yu, MD, PhD, Professor, Surgeon, Department of Orthopedics, Nanfang Hospital, Southern Medical University, No. 1838, Guangzhou Ave. North, Baiyun District, Guangzhou 510515, Guangdong Province, China. smuyubin@163.com |
Key Words |
Neuropeptide Y; Bone marrow mesenchymal stem cells; Hematopoietic stem cells; Fracture; Osteoporosis; Osteoarthritis |
Core Tip |
Neuropeptide Y (NPY) system is crucial for bone metabolism and homeostasis. NPY can regulate biological effects of different types of cells through central and peripheral nervous systems. Here, we summarized recent findings regarding the roles of NPY and its receptors in bone metabolism and homeostasis, discussed biological actions and underlying mechanisms of NPY on bone marrow mesenchymal stem cells, hematopoietic stem cells, endothelial cells and chondrocytes. We also reviewed potential applications and efficacy of NPY and NPY receptor-targeted drugs in the treatment of fracture healing, osteoporosis and osteoarthritis. |
Publish Date |
2020-09-22 06:23 |
Citation |
Wu JQ, Jiang N, Yu B. Mechanisms of action of neuropeptide Y on stem cells and its potential applications in orthopaedic disorders. World J Stem Cells 2020; 12(9): 986-1000 |
URL |
https://www.wjgnet.com/1948-0210/full/v12/i9/986.htm |
DOI |
https://dx.doi.org/10.4252/wjsc.v12.i9.986 |
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