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Articles Published Processes
9/4/2020 7:25:49 AM | Browse: 1068 | Download: 2707
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Received |
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2020-05-17 09:25 |
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Peer-Review Started |
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2020-05-17 09:26 |
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First Decision by Editorial Office Director |
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2020-06-18 05:58 |
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Return for Revision |
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2020-06-18 05:58 |
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Revised |
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2020-06-27 03:23 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2020-08-11 12:32 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2020-08-12 07:22 |
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Articles in Press |
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2020-08-12 07:22 |
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Edit the Manuscript by Language Editor |
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2020-08-18 01:19 |
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Typeset the Manuscript |
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2020-08-31 00:53 |
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Publish the Manuscript Online |
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2020-09-04 07:25 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Resveratrol alleviates intestinal mucosal barrier dysfunction in dextran sulfate sodium-induced colitis mice by enhancing autophagy
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hang-Hai Pan, Xin-Xin Zhou, Ying-Yu Ma, Wen-Sheng Pan, Fei Zhao, Mo-Sang Yu and Jing-Quan Liu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Nature Science Foundation of China |
81600414 |
| Medical Health Science and Technology Project of Zhejiang Provincial Health Commission |
2018255969 |
| Zhejiang TCM Science and Technology Project |
2016ZA123 |
| Zhejiang TCM Science and Technology Project |
2018ZA013 |
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| Corresponding Author |
Ying-Yu Ma, MD, Research Associate, Key laboratory of gastroenterology of Zhejiang province, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, No.158 Shangtang Road, Hangzhou 310014, Zhejiang Province, China. myy011525@163.com |
| Key Words |
Resveratrol; Ulcerative colitis; Autophagy; Intestinal mucosal barrier; Dextran sulfate sodium-induced colitis; Intestinal inflammation |
| Core Tip |
We established a chronic colitis model successfully via the administration of dextran sulfate sodium (DSS), and we found that resveratrol ameliorates the production of the inflammatory cytokines in DSS-induced colitis mice. Meanwhile, resveratrol treatment alleviated intestinal mucosal barrier dysfunction in DSS-induced colitis and increased the expression of the tight junction proteins occludin and ZO-1. Further study showed that resveratrol treatment increased the levels of LC3B and Beclin-1 in the colons of colitis mice, as well as the number of autophagosomes, which may via enhancing autophagy. |
| Publish Date |
2020-09-04 07:25 |
| Citation |
Pan HH, Zhou XX, Ma YY, Pan WS, Zhao F, Yu MS, Liu JQ. Resveratrol alleviates intestinal mucosal barrier dysfunction in dextran sulfate sodium-induced colitis mice by enhancing autophagy. World J Gastroenterol 2020; 26(33): 4945-4959
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| URL |
https://www.wjgnet.com/1007-9327/full/v26/i33/4945.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i33.4945 |
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