BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
10/24/2020 2:27:20 AM | Browse: 879 | Download: 1748
 |
Received |
|
2020-06-13 05:34 |
|
Peer-Review Started |
|
2020-06-13 05:35 |
|
First Decision by Editorial Office Director |
|
2020-07-30 23:30 |
|
Return for Revision |
|
2020-07-30 23:30 |
|
Revised |
|
2020-08-01 17:26 |
 |
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2020-09-25 09:31 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2020-09-25 19:18 |
|
Articles in Press |
|
2020-09-25 19:18 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2020-10-18 07:59 |
|
Publish the Manuscript Online |
|
2020-10-24 02:27 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Tumor necrosis family receptor superfamily member 9/tumor necrosis factor receptor-associated factor 1 pathway on hepatitis C viral persistence and natural history
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Julia Peña-Asensio, Eduardo Sanz-de-Villalobos, Joaquín Miquel and Juan Ramón Larrubia |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Instituto de Salud Carlos III and European Structural Funds in Spain; European Regional Development Fund |
PI19/00206 |
|
| Corresponding Author |
Juan Ramón Larrubia, MD, MSc, PhD, Senior Lecturer, Staff Physician, Translational Hepatology Unit, Guadalajara University Hospital, University of Alcalá, Donante de Sangre St, Guadalajara E-19002, Guadalajara, Spain. juan.larrubia@uah.es |
| Key Words |
Hepatitis C virus; Tumor necrosis factor receptor-associated factor 1; CD8; Exhaustion; Tumor necrosis family receptor superfamily member 9; Chronic hepatitis |
| Core Tip |
Tumor necrosis factor receptor-associated factor 1 (TRAF1) is the signal transducer of the positive checkpoint tumor necrosis family receptor superfamily member 9 (4-1BB), essential in the activation of adaptive immune response. During persistent hepatitis C virus (HCV) infection, this transducer is down-regulated via transforming growth factor beta 1, linked to T cell exhaustion. Interleukin-7 can restore TRAF1 expression and improve T cell reactivity but only in patients with mild evolution, while cases with a more aggressive progression also need the modulation of other negative co-stimulatory molecules. Therefore, TRAF1 dynamics defines a new pathogenic model that explains the different level of T cell exhaustion and progression during HCV infection and supports the rationale for immunotherapeutic strategies in chronic viral infections. |
| Publish Date |
2020-10-24 02:27 |
| Citation |
Peña-Asensio J, Sanz-de-Villalobos E, Miquel J, Larrubia JR. Tumor necrosis family receptor superfamily member 9/tumor necrosis factor receptor-associated factor 1 pathway on hepatitis C viral persistence and natural history. World J Hepatol 2020; 12(10): 754-765 |
| URL |
https://www.wjgnet.com/1948-5182/full/v12/i10/754.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v12.i10.754 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
