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Articles Published Processes
1/21/2021 3:12:07 AM | Browse: 546 | Download: 1276
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Received |
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2020-08-11 11:53 |
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Peer-Review Started |
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2020-08-11 11:54 |
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To Make the First Decision |
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Return for Revision |
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2020-10-23 21:07 |
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Revised |
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2020-11-02 07:22 |
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Second Decision |
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2020-11-17 12:17 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-11-17 22:50 |
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Articles in Press |
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2020-11-17 22:50 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-11-30 23:55 |
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Typeset the Manuscript |
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2021-01-06 02:59 |
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Publish the Manuscript Online |
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2021-01-21 03:12 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Proliferation and tenogenic differentiation of bone marrow mesenchymal stem cells in a porous collagen sponge scaffold
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Bing-Yu Zhang, Pu Xu, Qing Luo and Guan-Bin Song |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural National Science Foundation of China |
No. 31700810 and 11772073 |
| Science and Technology Research Program of Chongqing Municipal Education Commission |
No. KJQN201800601 |
| Natural Science Foundation of Chongqing, China |
No. cstc2020jcyj-msxmX0760 |
| Visiting Scholar Foundation of Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education |
No. CQKLBST-2018-007 |
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| Corresponding Author |
Guan-Bin Song, PhD, Professor, Department of College of Bioengineering, Chongqing University, No. 174 Shazhengjie, Shapingba, Chongqing 400030, China. song@cqu.edu.cn |
| Key Words |
Bone marrow mesenchymal stem cells; Collagen sponge; Transforming growth factor β1; Tenogenic differentiation; Proliferation; Collagen deposition |
| Core Tip |
Growth factor supplementation of stem cells facilitates cell differentiation and/or cell growth, but there is an incomplete understanding of which growth factors are optimal in 3D culture. We compared different growth factors for the proliferation and tenogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) in a monolayer culture (2D) and in a collagen sponge-based 3D culture. We found that transforming growth factor β1 (TGF-β1) showed great promise in the tenogenic differentiation of BMSCs compared to growth differentiation factor 7 and insulin-like growth factor 1 in both 2D and 3D cultures, and the 3D culture enhanced the tenogenic differentiation of BMSCs well beyond the level of induction in the 2D culture after TGF-β1 treatment. |
| Publish Date |
2021-01-21 03:12 |
| Citation |
Zhang BY, Xu P, Luo Q, Song GB. Proliferation and tenogenic differentiation of bone marrow mesenchymal stem cells in a porous collagen sponge scaffold. World J Stem Cells 2021; 13(1): 115-127 |
| URL |
https://www.wjgnet.com/1948-0210/full/v13/i1/115.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v13.i1.115 |
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