Publication Name	World Journal of Gastroenterology
Manuscript ID	59172
Country	Japan

Received	2020-08-28 18:02
Peer-Review Started	2020-08-28 18:02
To Make the First Decision
Return for Revision	2020-11-03 14:57
Revised	2020-11-17 10:43
Second Decision	2020-12-29 02:20
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2020-12-29 19:31
Articles in Press	2020-12-29 19:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-01-21 05:15
Publish the Manuscript Online	2021-02-20 02:51

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Clinical and Translational Research
Article Title	Quantitative multiparametric magnetic resonance imaging can aid non-alcoholic steatohepatitis diagnosis in a Japanese cohort
Manuscript Source	Unsolicited Manuscript
All Author List	Kento Imajo, Louise Tetlow, Andrea Dennis, Elizabeth Shumbayawonda, Sofia Mouchti, Timothy J Kendall, Eve Fryer, Shogi Yamanaka, Yasushi Honda, Takaomi Kessoku, Yuji Ogawa, Masato Yoneda, Satoru Saito, Catherine Kelly, Matt D Kelly, Rajarshi Banerjee and Atsushi Nakajima
ORCID	Author(s) ORCID Number Kento Imajo http://orcid.org/0000-0002-1931-6326 Louise Tetlow http://orcid.org/0000-0001-6285-4878 Andrea Dennis http://orcid.org/0000-0002-0152-6528 Elizabeth Shumbayawonda http://orcid.org/0000-0003-0351-2063 Sofia Mouchti http://orcid.org/0000-0002-3169-5242 Timothy J Kendall http://orcid.org/0000-0002-4174-2786 Eve Fryer http://orcid.org/0000-0003-1385-6433 Shogi Yamanaka http://orcid.org/0000-0001-8882-3981 Yasushi Honda http://orcid.org/0000-0002-1624-5462 Takaomi Kessoku http://orcid.org/0000-0002-5587-1386 Yuji Ogawa http://orcid.org/0000-0001-7033-088X Masato Yoneda http://orcid.org/0000-0001-7815-549X Satoru Saito http://orcid.org/0000-0002-5666-5218 Catherine Kelly http://orcid.org/0000-0002-5834-1234 Matt D Kelly http://orcid.org/0000-0002-5834-635X Rajarshi Banerjee http://orcid.org/0000-0003-2022-5218 Atsushi Nakajima http://orcid.org/0000-0002-6263-1436
Funding Agency and Grant Number
Corresponding Author	Andrea Dennis, PhD, Research Scientist, Innovation, Perspectum, Gemini One, 5520 John Smith Drive, Oxford OX4 2LL, United Kingdom. andrea.dennis@perspectum.com
Key Words	Corrected T1; Fibro-inflammation; Non-invasive imaging; Non-alcoholic steatohepatitis; Multiparametric magnetic resonance imaging; Non-alcoholic fatty liver disease
Core Tip	There is growing interest in the utility of non-invasive tests in the management of non-alcoholic steatohepatitis or non-alcoholic steatohepatitis (NASH). We explored how magnetic resonance imaging technology can stratify patients with simple fatty liver disease from those with NASH. Our results showed that quantitative magnetic resonance imaging derived metrics showed the strong correlations to the histological pathological components of NASH with very few technical failures. We also observed very high levels of inter-reader disagreement in histopathological biopsy reads, highlighting the pressing need for alternative diagnostic tests for NASH. Our work therefore supports the use this non-invasive technology in day-to-day practice.
Publish Date	2021-02-20 02:51
Citation	Imajo K, Tetlow L, Dennis AM, Shumbayawonda E, Mouchti S, Kendall TJ, Fryer E, Yamanaka S, Honda Y, Kessoku T, Ogawa Y, Yoneda M, Saito S, Kelly C, Kelly MD, Banerjee R, Nakajima A. Quantitative multiparametric magnetic resonance imaging can aid non-alcoholic steatohepatitis diagnosis in a Japanese cohort. World J Gastroenterol 2021; 27(7): 609-623
URL	https://www.wjgnet.com/1007-9327/full/v27/i7/609.htm
DOI	https://dx.doi.org/10.3748/wjg.v27.i7.609

Full Article (PDF)	WJG-27-609.pdf
Full Article (Word)	WJG-27-609.docx
Manuscript File	59172_Auto_Edited_LM.docx
Answering Reviewers	59172-Answering reviewers.pdf
Audio Core Tip	59172-Audio core tip.m4a
Biostatistics Review Certificate	59172-Biostatistics statement.pdf
Clinical Trial Registration Statement	59172-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	59172-Conflict-of-interest statement.pdf
Copyright License Agreement	59172-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	59172-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	59172-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	59172-Language certificate.pdf
Peer-review Report	59172-Peer-review(s).pdf
Scientific Misconduct Check	59172-Bing-Yan JP-1.png
Scientific Misconduct Check	59172-Scientific misconduct check.pdf
Scientific Editor Work List	59172-Scientific editor work list.pdf
CrossCheck Report	59172-CrossCheck Report.pdf