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Articles Published Processes
11/23/2020 10:54:17 AM | Browse: 594 | Download: 1025
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Received |
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2020-09-02 08:09 |
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Peer-Review Started |
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2020-08-31 15:26 |
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To Make the First Decision |
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Return for Revision |
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2020-10-23 18:12 |
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Revised |
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2020-11-06 10:50 |
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Second Decision |
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2020-11-17 12:19 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2020-11-17 22:56 |
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Articles in Press |
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2020-11-17 22:56 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-11-19 14:21 |
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Publish the Manuscript Online |
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2020-11-23 10:54 |
| ISSN |
2220-3230 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Transplantation |
| Manuscript Type |
Minireviews |
| Article Title |
Extracellular vesicles as mediators of alloimmunity and their therapeutic potential in liver transplantation
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Sotiris Mastoridis, Marc Martinez-Llordella and Alberto Sanchez‐Fueyo |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Sotiris Mastoridis, MBBS, PhD, Doctor, Department of Surgery, Oxford University Hospitals, Churchill Hospital, Old Road, Oxford, Oxford OX37LE, United Kingdom. sotiris.mastoridis@googlemail.com |
| Key Words |
Extracellular vesicle; Transplantation; Liver; Alloimmunity; Tolerance; Therapy |
| Core Tip |
Extracellular vesicles (EVs) are key contributors to T cell alloimmunity through the transfer of major histocompatibility alloantigens to host antigen presenting cells (APCs) thereby initiating alloresponses and acute rejection. Strong circumstantial evidence suggests that under certain conditions EV-mediated cross-dressing of recipient APCs can also tolerance responses and allay allograft rejection–for instance in the context of liver transplantation. We anticipate improved mechanistic understanding of these processes will facilitate design of novel EV therapies in transplantation. A number of clinical trials assessing the safety and efficacy of EVs are underway. The substantial developments in engineered Good Manufacture Practices-grade EVs hold promise for novel EV-therapeutics in transplantation and beyond. |
| Publish Date |
2020-11-23 10:54 |
| Citation |
Mastoridis S, Martinez-Llordella M, Sanchez-Fueyo A. Extracellular vesicles as mediators of alloimmunity and their therapeutic potential in liver transplantation. World J Transplant 2020; 10(11): 330-344 |
| URL |
https://www.wjgnet.com/2220-3230/full/v10/i11/330.htm |
| DOI |
https://dx.doi.org/10.5500/wjt.v10.i11.330 |
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