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Articles Published Processes
3/3/2021 10:02:01 AM | Browse: 479 | Download: 1037
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Received |
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2020-09-11 22:14 |
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Peer-Review Started |
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2020-09-11 22:14 |
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To Make the First Decision |
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Return for Revision |
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2020-11-25 20:24 |
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Revised |
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2020-12-08 23:31 |
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Second Decision |
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2021-01-15 13:40 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-01-15 17:38 |
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Articles in Press |
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2021-01-15 17:38 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-03-02 11:36 |
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Publish the Manuscript Online |
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2021-03-03 10:02 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Effect of acetyl-L-carnitine on hypersensitivity in acute recurrent caerulein-induced pancreatitis and microglial activation along the brain’s pain circuitry
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Sabrina L McIlwrath, Marlene E Starr, Abigail E High, Hiroshi Saito and Karin N Westlund |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| United States Department of Veterans Affairs, VA Merit Grant |
BX002695 |
| United States National Institute of Health |
R01AG055359 |
| United States National Institute of Health |
R01GM126181 |
| United States National Institute of Health |
R01NS39041-15 |
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| Corresponding Author |
Sabrina L McIlwrath, PhD, Senior Scientist, Research Service, New Mexico Veterans Affairs Healthcare System, 1501 San Pedro SE, Albuquerque, NM 87108, United States. sabrina.mcilwrath@va.gov |
| Key Words |
Acute recurrent pancreatitis; Neuropathic pain; Mechanical hypersensitivity; Heat hypersensitivity; Anxiety-like behavior; Ionized calcium-binding adaptor molecule 1 |
| Core Tip |
The caerulein- (CAE) induced pancreatitis model requiring 6 wk of repeated injections is a model of recurrent acute bouts of pancreatitis that causes pancreatic tissue damage and fibrosis. Control repeated i.p. saline injections alone caused abdominal wall injury and hindpaw secondary mechanical hypersensitivity. Treatment with acetyl-L-carnitine significantly attenuated CAE-induced hypersensitivity without alleviating pancreatic histological disruption. Mice with CAE-induced pancreatitis with secondary mechanical and heat hypersensitivity had elevated plus maze anxiety-like behavior. Post-mortem analysis revealed microglial morphology changes indicative of activation in amygdala, hippocampus, hypothalamus, and thalamus, but not in primary somatosensory cortex. These data suggest that activated microglia in these brain regions contribute to chronic hypersensitivity and anxiety-like behaviors in mice with CAE-induced pancreatitis. |
| Publish Date |
2021-03-03 10:02 |
| Citation |
McIlwrath SL, Starr ME, High AE, Saito H, Westlund KN. Effect of acetyl-L-carnitine on hypersensitivity in acute recurrent caerulein-induced pancreatitis and microglial activation along the brain’s pain circuitry. World J Gastroenterol 2021; 27(9): 794-814 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i9/794.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i9.794 |
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