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Articles Published Processes
4/22/2021 12:14:42 PM | Browse: 399 | Download: 1097
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Received |
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2020-12-22 10:32 |
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Peer-Review Started |
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2020-12-22 10:32 |
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To Make the First Decision |
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Return for Revision |
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2021-01-10 21:26 |
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Revised |
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2021-01-15 11:09 |
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Second Decision |
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2021-02-23 03:15 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-02-26 16:29 |
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Articles in Press |
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2021-02-26 16:29 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-03-12 02:15 |
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Typeset the Manuscript |
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2021-04-11 22:49 |
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Publish the Manuscript Online |
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2021-04-22 12:14 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Respiratory System |
| Manuscript Type |
Case Report |
| Article Title |
Pulmonary arterial hypertension in a patient with hereditary hemorrhagic telangiectasia and family gene analysis: A case report
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jian Wu, Yuan Yuan, Xin Wang, Dong-Ying Shao, Li-Guo Liu, Jian He and Peng Li |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Peng Li, MD, PhD, Attending Doctor, Department of Pulmonary and Critical Care Medicine, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang 110004, Liaoning Province, China. lipengcmu@163.com |
| Key Words |
Hereditary hemorrhagic telangiectasia; Pulmonary arterial hypertension; Activin A receptor-like type 1; Activin receptor-like kinase 1; Arteriovenous malformation; Endothelin receptor antagonist; Case report |
| Core Tip |
Hereditary hemorrhagic telangiectasia (HHT) is a rare autosomal dominant genetic disease, which when associated with pulmonary arterial hypertension (PAH) may result in poor prognosis. As there are many susceptible gene mutations in PAH, there is no clear genetic evidence for HHT with PAH. This is the first report of the activin A receptor-like type 1 c. 1232G>A, p. Arg411Gln mutation in Chinese HHT patients with PAH. The patient's condition improved obviously after ambrisentan treatment, rather than bosentan. The patient and familial HHT diagnosis was made after the proband’s admission with severe PAH and heart failure. This overdue diagnosis reflects insufficient awareness for HHT diagnosis. |
| Publish Date |
2021-04-22 12:14 |
| Citation |
Wu J, Yuan Y, Wang X, Shao DY, Liu LG, He J, Li P. Pulmonary arterial hypertension in a patient with hereditary hemorrhagic telangiectasia and family gene analysis: A case report. World J Clin Cases 2021; 9(13): 3079-3089 |
| URL |
https://www.wjgnet.com/2307-8960/full/v9/i13/3079.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v9.i13.3079 |
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