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Articles Published Processes
10/15/2021 9:45:09 AM | Browse: 360 | Download: 785
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Received |
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2020-12-23 02:27 |
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Peer-Review Started |
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2020-12-16 00:32 |
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To Make the First Decision |
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Return for Revision |
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2021-07-16 03:30 |
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Revised |
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2021-07-28 14:27 |
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Second Decision |
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2021-09-07 03:25 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-09-08 10:31 |
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Articles in Press |
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2021-09-08 10:31 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-10-09 03:12 |
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Publish the Manuscript Online |
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2021-10-15 09:45 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Reproductive Biology |
| Manuscript Type |
Case Report |
| Article Title |
Whole-genome amplification/preimplantation genetic testing for propionic acidemia of successful pregnancy in an obligate carrier Mexican couple: A case report
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Adina Neumann, Miguel Angel Alcantara-Ortigoza, Ariadna González-del Angel, Nestor Alejandro Zarate Díaz, Javier Sam Santana, Leonardo M Porchia and Esther López-Bayghen |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Esther López-Bayghen, PhD, Professor, Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Avenida Instituto Politécnico Nacional 2508, San Pedro Zacatenco, Mexico City 07360, Mexico. ebayghen@cinvestav.mx |
| Key Words |
Propionic acidemia; Autosomal recessive; Propionyl-CoA carboxylase subunit alpha gene; Preimplantation genetic testing; Next-generation sequencing; Embryo transfer |
| Core Tip |
Propionic acidemia is an uncommon monogenetic disorder resulting in inherited severe complications and death. A heterozygous genotype for a pathogenic variant of the propionyl-Coenzyme A carboxylase alpha-subunit gene was located in a fertile Mexican couple. Here we show that a couple can reduce the transmission of a pathogenic variant of a gene using in vitro fertilization, genetic counseling, and sequencing of a whole genome amplification template. Furthermore, after embryo transfer, we report the delivery of a healthy male newborn without propionic acidemia. |
| Publish Date |
2021-10-15 09:45 |
| Citation |
Neumann A, Alcantara-Ortigoza MÁ, González-del Ángel A, Zarate Díaz NA, Santana JS, Porchia LM, López-Bayghen E. Whole genome amplification/preimplantation genetic testing for propionic acidemia resulting in a successful pregnancy in an obligate carrier Mexican couple: A case report. World J Clin Cases 2021; 9(29): 8797-8803 |
| URL |
https://www.wjgnet.com/2307-8960/full/v9/i29/8797.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v9.i29.8797 |
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