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Articles Published Processes
4/2/2021 12:29:14 PM | Browse: 550 | Download: 1267
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Received |
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2020-12-21 11:29 |
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Peer-Review Started |
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2020-12-18 01:47 |
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To Make the First Decision |
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Return for Revision |
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2021-01-17 06:14 |
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Revised |
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2021-01-18 05:36 |
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Second Decision |
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2021-01-30 14:22 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-02-01 19:12 |
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Articles in Press |
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2021-02-01 19:12 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-02-09 00:45 |
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Typeset the Manuscript |
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2021-03-16 05:59 |
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Publish the Manuscript Online |
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2021-04-02 12:29 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.v |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Neurosciences |
| Manuscript Type |
Case Report |
| Article Title |
Melatonin for an obese child with MC4R gene variant showing epilepsy and disordered sleep: A case report
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wen-Rong Ge, Lin Wan and Guang Yang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81671279 |
| Big Data and Artificial Intelligence Research and Development Project of the Chinese PLA General Hospital |
2019MBD-004 |
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| Corresponding Author |
Guang Yang, PhD, Professor, Department of Pediatrics, The First Medical Center of Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. yangguang74@301hospital.com.cn |
| Key Words |
Melanocortin receptor 4; Obesity; Sleep disorders; Epilepsy; Melatonin; Case report |
| Core Tip |
Numerous reports suggested that abnormalities of the MC4R (melanocortin receptor 4) gene may cause obesity, but are rarely associated with other conditions. The case presented in our manuscript involved a male obese child with a heterozygous variant in MC4R (c.494G>A, p.Arg165Gln) inherited from his father, who presented with epilepsy, sleep disordered and his melatonin rhythm was markedly distorted. This is the first report of the combination of these symptoms in a patient with an MC4R variant. Antiepileptic drug was ineffective and the sleep disorder appeared to be deteriorating. The use of melatonin relieved all his symptoms, and even the electroencephalography review was normal, and a typical melatonin rhythm was restored. We hope that our experience can help for the early diagnosis and treatment of this condition. |
| Publish Date |
2021-04-02 12:29 |
| Citation |
Ge WR, Wan L, Yang G. Melatonin for an obese child with MC4R gene variant showing epilepsy and disordered sleep: A case report. World J Clin Cases 2021; 9(11): 2688-2695 |
| URL |
https://www.wjgnet.com/2307-8960/full/v9/i11/2688.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v9.i11.2688 |
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