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Articles Published Processes
8/24/2021 2:07:00 AM | Browse: 292 | Download: 594
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Received |
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2020-12-31 02:42 |
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Peer-Review Started |
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2020-12-31 02:44 |
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To Make the First Decision |
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Return for Revision |
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2021-06-15 05:51 |
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Revised |
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2021-06-25 07:26 |
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Second Decision |
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2021-07-06 05:46 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-07-06 06:09 |
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Articles in Press |
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2021-07-06 06:09 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-07-19 01:10 |
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Typeset the Manuscript |
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2021-08-13 02:24 |
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Publish the Manuscript Online |
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2021-08-24 02:07 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Neurosciences |
| Manuscript Type |
Case Report |
| Article Title |
Late-onset Leigh syndrome without delayed development in China: A case report
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jian-Min Liang, Cui-Juan Xin, Guang-Liang Wang and Xue-Mei Wu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81801284 |
| National Natural Science Foundation of China |
81771396 |
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| Corresponding Author |
Xue-Mei Wu, MD, Doctor, Doctor, Department of Pediatric Neurology, 1st hospital of Jilin University, No. 1 Xinmin Street, Changchun 130021, Jilin Province, China. xmwu@jlu.edu.cn |
| Key Words |
Leigh syndrome; 9176 mutation; Late-onset; Case report |
| Core Tip |
Leigh syndrome (LS) often manifests as early-onset with delayed phenotypic development. However, late-onset LS with normal development and white matter lesions in the brain is rarely reported. Here, we present a late-onset LS case of a previously healthy12-year-old boy that suddenly and unexpectedly died within 2 mo after the onset of symptom that included myasthenia oculi and subsequent energy failure. Gene analysis revealed that the boy had a T-to-C transition at nucleotide 9176 of the mitochondrial ATPase 6 gene. The current case is reported for the first time in China and highlights the variability of phenotypic expression of LS. |
| Publish Date |
2021-08-24 02:07 |
| Citation |
Liang JM, Xin CJ, Wang GL, Wu XM. Late-onset Leigh syndrome without delayed development in China: A case report. World J Clin Cases 2021; 9(24): 7133-7138 |
| URL |
https://www.wjgnet.com/2307-8960/full/v9/i24/7133.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v9.i24.7133 |
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