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Articles Published Processes
7/6/2021 11:59:03 PM | Browse: 380 | Download: 843
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Received |
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2021-01-20 10:52 |
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Peer-Review Started |
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2021-01-20 10:54 |
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To Make the First Decision |
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Return for Revision |
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2021-02-15 01:24 |
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Revised |
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2021-02-18 11:51 |
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Second Decision |
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2021-04-22 06:05 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-04-22 11:47 |
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Articles in Press |
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2021-04-22 11:47 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-07-01 04:37 |
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Typeset the Manuscript |
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2021-07-05 05:28 |
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Publish the Manuscript Online |
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2021-07-06 23:59 |
| ISSN |
2220-3141(online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Critical Care Medicine |
| Manuscript Type |
Minireviews |
| Article Title |
Glucocorticoid and mineralocorticoid receptor expression in critical illness: A narrative review
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Alice G Vassiliou, Nikolaos Athanasiou, Dimitra A Vassiliadi, Edison Jahaj, Chrysi Keskinidou, Anastasia Kotanidou and Ioanna Dimopoulou |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ioanna Dimopoulou, MD, PhD, Professor, 1st Department of Critical Care Medicine & Pulmonary Services, School of Medicine, National & Kapodistrian University of Athens, “Evangelismos” Hospital, Ipsilantou 45-47, Athens 10676, Greece. idimo@otenet.gr |
| Key Words |
Mineralocorticoid receptor; Glucocorticoid receptor, Critical illness; 11beta-hydroxysteroid dehydrogenase; Aldosterone; Cortisol |
| Core Tip |
Endogenous glucocorticoids (GCs) play a critical role in controlling inflammatory responses in critical illness. Intracellular GC concentrations can differ greatly due to the action of the two 11β-hydroxysteroid dehydrogenase isozymes. The degree of expression of the two isozymes has the potential to dramatically influence local GC availability. The GC receptor (GCR) and the mineralocorticoid receptor (MR) are members of the steroid receptor superfamily of hormone-dependent transcription factors. The study of MR and GCR expression and function in the inflammatory response seen in critical illness, might aid in identifying the patients who will benefit from exogenous corticosteroid administration. |
| Publish Date |
2021-07-06 23:59 |
| Citation |
Vassiliou AG, Athanasiou N, Vassiliadi DA, Jahaj E, Keskinidou C, Kotanidou A, Dimopoulou I. Glucocorticoid and mineralocorticoid receptor expression in critical illness: A narrative review. World J Crit Care Med 2021; 10(4): 102-111 |
| URL |
https://www.wjgnet.com/2220-3141/full/v10/i4/102.htm |
| DOI |
https://dx.doi.org/ 10.5492/wjccm.v10.i4.102 |
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