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Articles Published Processes
7/23/2021 1:30:21 PM | Browse: 503 | Download: 875
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Received |
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2021-01-27 10:40 |
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Peer-Review Started |
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2021-01-27 10:43 |
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To Make the First Decision |
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Return for Revision |
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2021-02-28 05:38 |
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Revised |
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2021-03-09 16:45 |
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Second Decision |
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2021-04-06 08:14 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-04-14 14:48 |
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Articles in Press |
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2021-04-14 14:48 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-06-25 08:13 |
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Typeset the Manuscript |
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2021-07-19 02:12 |
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Publish the Manuscript Online |
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2021-07-23 13:30 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
Mechanisms involved in selecting and maintaining neuroblastoma cancer stem cell populations, and perspectives for therapeutic targeting
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Antonietta Rosella Farina, Lucia Annamaria Cappabianca, Veronica Zelli, Michela Sebastiano and Andrew Reay Mackay |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Andrew Reay Mackay, PhD, Associate Professor, Department of Applied Clinical and Biotechnological Sciences, University of L'Aquila, Via Vetoio, Coppito 2, L'Aquila 67100, AQ, Italy. andrewreay.mackay@univaq.it |
| Key Words |
Neural crest; Neuroblastoma; Cancer stem cells; Polyploid giant cancer cells molecular mechanisms; Therapeutic targeting; Tumor microenvironment |
| Core Tip |
Cancer stem cells promote tumor-heterogeneity, post-therapeutic relapse and metastatic progression in neuroblastomas, by way of their drug-resistant, self-renewing and reversibly plastic phenotypes, and are, therefore, critical targets to eliminate if improvements in therapeutic outcomes are to be realized. Despite progress in understanding molecular mechanisms that underpin neuroblastomas (NB) cancer stem cell (CSC) selection, promotion and maintenance, efficacious CSC targeting remains difficult. Here we review molecular mechanisms considered to regulate NB CSCs, married with therapeutic strategies and future prospects for their eradication, highlighting the need for better understanding and targeting of polyploid giant cancer cell states, future prospects for CAR cell immunotherapies, the need to identify additional functional cell surface NB CSC-specific targets and to develop better models for NB CSC experimental therapeutics. |
| Publish Date |
2021-07-23 13:30 |
| Citation |
Farina AR, Cappabianca LA, Zelli V, Sebastiano M, Mackay AR. Mechanisms involved in selecting and maintaining neuroblastoma cancer stem cell populations, and perspectives for therapeutic targeting. World J Stem Cells 2021; 13(7): 685-736 |
| URL |
https://www.wjgnet.com/1948-0210/full/v13/i7/685.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v13.i7.685 |
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