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Articles Published Processes
4/22/2021 10:31:45 AM | Browse: 496 | Download: 1067
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Received |
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2021-02-01 16:59 |
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Peer-Review Started |
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2021-02-01 17:10 |
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To Make the First Decision |
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Return for Revision |
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2021-02-28 05:24 |
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Revised |
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2021-03-11 18:22 |
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Second Decision |
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2021-03-29 10:16 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-03-30 04:13 |
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Articles in Press |
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2021-03-30 04:13 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-04-05 00:51 |
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Typeset the Manuscript |
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2021-04-20 06:32 |
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Publish the Manuscript Online |
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2021-04-22 10:31 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Review |
| Article Title |
Patient-specific induced pluripotent stem cells as “disease-in-a-dish” models for inherited cardiomyopathies and channelopathies – 15 years of research
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Miruna Mihaela Micheu and Ana-Maria Rosca |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Miruna Mihaela Micheu, MD, PhD, Doctor, Doctor, Department of Cardiology, Clinical Emergency Hospital of Bucharest, Floreasca Street 8, Bucharest 014452, Romania. mirunamicheu@yahoo.com |
| Key Words |
Induced pluripotent stem cells; Cardiomyopathy; Channelopathy; Genes; Mutation; Deoxyribonucleic acid variants |
| Core Tip |
Induced pluripotent stem cell (iPSC) technology holds a great potential for medical research. Patient-specific iPSC-derived cardiomyocytes offer an unique framework for various applications such as cardiotoxicity screening, drug discovery, disease modeling, and cell therapy. In the particular case of inherited cardiomyopathies and channelopathies, iPSC-based models prompted the study of disease mechanisms in an individual-/allele-specific manner, as well as the customization of therapeutic regimen. Herein, we will present and critically discuss the current knowledge and key experimental approaches, which qualifies patient-specific iPSCs as robust “disease-in-a-dish” models for genetic cardiomyopathies and channelopathies after 15 years of research. |
| Publish Date |
2021-04-22 10:31 |
| Citation |
Micheu MM, Rosca AM. Patient-specific induced pluripotent stem cells as “disease-in-a-dish” models for inherited cardiomyopathies and channelopathies – 15 years of research. World J Stem Cells 2021; 13(4): 281-303 |
| URL |
https://www.wjgnet.com/1948-0210/full/v13/i4/281.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v13.i4.281 |
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