BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
4/22/2021 10:31:45 AM | Browse: 726 | Download: 1612
 |
Received |
|
2021-02-01 16:59 |
|
Peer-Review Started |
|
2021-02-01 17:10 |
|
First Decision by Editorial Office Director |
|
2021-02-28 05:24 |
|
Return for Revision |
|
2021-02-28 05:24 |
|
Revised |
|
2021-03-11 18:22 |
 |
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2021-03-29 10:16 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2021-03-30 04:13 |
|
Articles in Press |
|
2021-03-30 04:13 |
|
Edit the Manuscript by Language Editor |
|
2021-04-05 00:51 |
|
Typeset the Manuscript |
|
2021-04-20 06:32 |
|
Publish the Manuscript Online |
|
2021-04-22 10:31 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Review |
| Article Title |
Patient-specific induced pluripotent stem cells as “disease-in-a-dish” models for inherited cardiomyopathies and channelopathies – 15 years of research
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Miruna Mihaela Micheu and Ana-Maria Rosca |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Miruna Mihaela Micheu, MD, PhD, Doctor, Doctor, Department of Cardiology, Clinical Emergency Hospital of Bucharest, Floreasca Street 8, Bucharest 014452, Romania. mirunamicheu@yahoo.com |
| Key Words |
Induced pluripotent stem cells; Cardiomyopathy; Channelopathy; Genes; Mutation; Deoxyribonucleic acid variants |
| Core Tip |
Induced pluripotent stem cell (iPSC) technology holds a great potential for medical research. Patient-specific iPSC-derived cardiomyocytes offer an unique framework for various applications such as cardiotoxicity screening, drug discovery, disease modeling, and cell therapy. In the particular case of inherited cardiomyopathies and channelopathies, iPSC-based models prompted the study of disease mechanisms in an individual-/allele-specific manner, as well as the customization of therapeutic regimen. Herein, we will present and critically discuss the current knowledge and key experimental approaches, which qualifies patient-specific iPSCs as robust “disease-in-a-dish” models for genetic cardiomyopathies and channelopathies after 15 years of research. |
| Publish Date |
2021-04-22 10:31 |
| Citation |
Micheu MM, Rosca AM. Patient-specific induced pluripotent stem cells as “disease-in-a-dish” models for inherited cardiomyopathies and channelopathies – 15 years of research. World J Stem Cells 2021; 13(4): 281-303 |
| URL |
https://www.wjgnet.com/1948-0210/full/v13/i4/281.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v13.i4.281 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
