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Articles Published Processes
5/27/2021 9:41:33 AM | Browse: 457 | Download: 1444
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Received |
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2021-02-06 21:33 |
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Peer-Review Started |
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2021-02-06 21:45 |
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To Make the First Decision |
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Return for Revision |
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2021-03-14 04:26 |
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Revised |
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2021-03-30 08:05 |
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Second Decision |
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2021-05-10 09:35 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-05-10 09:50 |
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Articles in Press |
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2021-05-10 09:50 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-05-25 03:18 |
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Publish the Manuscript Online |
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2021-05-27 09:41 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medical Informatics |
| Manuscript Type |
Basic Study |
| Article Title |
Insight into molecular mechanisms underlying hepatic dysfunction in severe COVID-19 patients using systems biology
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Sarah Musa Hammoudeh, Arabella Musa Hammoudeh, Poorna Manasa Bhamidimarri, Bassam Mahboub, Rabih Halwani, Qutayba Hamid, Mohamed Rahmani and Rifat Hamoudi |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| University of Sharjah |
CoV19-0308 |
| University of Sharjah |
CoV19-0307 |
| University of Sharjah |
1901090254 |
| Sharjah Research Academy |
MED001 |
| Al-Jalila Foundation Seed Grant |
AJF202019 |
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| Corresponding Author |
Rifat Hamoudi, PhD, Professor, Sharjah Institute for Medical Research, College of Medicine, University of Sharjah, P.O. Box, Sharjah 27272, United Arab Emirates. rhamoudi@sharjah.ac.ae |
| Key Words |
COVID-19; Hepatic dysfunction; Tissue remodeling; Metabolic pathways; Drug metabolism; Hepatic detoxification |
| Core Tip |
Liver dysfunction was frequently observed in severe coronavirus disease 2019 (COVID-19) patients. However, the mechanism through which severe acute respiratory syndrome coronavirus 2 potentially elicits liver function abnormality is not fully understood. We report a thorough analysis of changes occurring at the gene expression level in liver tissue of severe COVID-19 patients. Our findings suggest that severe COVID-19 patients may have a lower hepatic detoxification capacity and may experience liver tissue remodeling resulting in liver dysfunction. |
| Publish Date |
2021-05-27 09:41 |
| Citation |
Hammoudeh SM, Hammoudeh AM, Bhamidimarri PM, Mahboub B, Halwani R, Hamid Q, Rahmani M, Hamoudi R. Insight into molecular mechanisms underlying hepatic dysfunction in severe COVID-19 patients using systems biology. World J Gastroenterol 2021; 27(21): 2850-2870 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i21/2850.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i21.2850 |
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