| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Topic Highlights |
| Article Title |
Targeting tight junctions during epithelial to mesenchymal transition in human pancreatic cancer
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Daisuke Kyuno, Hiroshi Yamaguchi, Tatsuya Ito, Tsuyoshi Kono, Yasutoshi Kimura, Masafumi Imamura, Takumi Konno, Koichi Hirata, Norimasa Sawada and Takashi Kojima |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Ministry of Education, Culture, Sports Science, and Technology, and the Ministry of Health, Labour and Welfare of Japan |
|
|
| Corresponding Author |
Takashi Kojima, PhD, Department of Cell Science, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, South 1, West 17, Sapporo 060-8556, Japan. ktakashi@sapmed.ac.jp |
| Key Words |
Tight junctions; Claudins; Tricellulin; Marveld3; Normal human pancreatic duct epithelial cells; Pancreatic cancer; protein kinase C; epithelial to mesenchymal transition |
| Core Tip |
There is an urgent need to develop novel diagnostic and therapeutic strategies to reduce the mortality of pancreatic cancer patients. In pancreatic cancer, some tight junction proteins, including claudins, are abnormally regulated and thus are promising molecular targets for Clostridium perfringens enterotoxin and monoclonal antibodies. Protein kinase C is closely related to epithelial to mesenchymal transition (EMT) of this cancer and regulates tight junctions of normal human pancreatic duct epithelial (HPDE) cells and pancreatic cancer cells. This review focuses on the regulation of tight junctions via protein kinase C during EMT in human pancreatic cancer compared to normal HPDE cells. |
| Publish Date |
2014-08-20 18:38 |
| Citation |
Kyuno D, Yamaguchi H, Ito T, Kono T, Kimura Y, Imamura M, Konno T, Hirata K, Sawada N, Kojima T. Targeting tight junctions during epithelial to mesenchymal transition in human pancreatic cancer. World J Gastroenterol 2014; 20(31): 10813-10824 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i31/10813.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i31.10813 |
