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Articles Published Processes
3/24/2022 2:13:21 PM | Browse: 273 | Download: 760
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Received |
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2021-03-29 09:27 |
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Peer-Review Started |
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2021-03-29 09:31 |
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To Make the First Decision |
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Return for Revision |
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2021-06-15 22:07 |
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Revised |
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2021-07-09 08:28 |
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Second Decision |
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2022-02-17 05:50 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-02-20 13:14 |
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Articles in Press |
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2022-02-20 13:14 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2022-01-05 11:11 |
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Typeset the Manuscript |
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2022-03-18 05:10 |
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Publish the Manuscript Online |
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2022-03-24 14:13 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pharmacology & Pharmacy |
| Manuscript Type |
Minireviews |
| Article Title |
New progress in understanding roles of nitric oxide during hepatic ischemia-reperfusion injury
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Yi-Ping Zhang, Xin-Ran Liu, Mei-Wen Yang, Shu-Long Yang and Fen-Fang Hong |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China (General Program) |
No. 81660151, No.81660751 and No. 82060661 |
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| Corresponding Author |
Fen-Fang Hong, MD, Associate Professor, Experimental Center of Pathogen Biology, College of Medicine, Nanchang University, No. 461 Bayi Road, Nanchang 330006, Jiangxi Province, China. hongfenfang@126.com |
| Key Words |
Hepatic ischemia-reperfusion injury; Nitric oxide; Endothelial nitric oxide synthase; Inducible nitric oxide synthase |
| Core Tip |
This review focuses on the new progress in the understanding of the role of nitric oxide (NO) in hepatic ischemia-reperfusion injury (HIRI). NO protects HIRI by increasing NO bioavailability and cellular autophagy, down-regulating leukotriene C4 synthase, inhibiting the nuclear factor κB (NF-κB) pathway, and reducing inflammatory cytokines and reactive oxygen species. While by regulating apoptotic factors, it has dual effects. eNOS exerts hepatoprotective effects by promoting NO production through the involvement of the phosphoinositide 3-kinase/Akt pathway and Kruppel-like factor 2/adenosine monophosphate-activated protein kinase pathways. The function of eNOS overexpression remains controversial. iNOS-derived NO mainly deteriorates HIRI, but it may reduce damage under certain conditions. The balance of eNOS and iNOS is important for the HIRI protection. |
| Publish Date |
2022-03-24 14:13 |
| Citation |
Zhang YP, Liu XR, Yang MW, Hong FF, Yang SL. New progress in understanding roles of nitric oxide during hepatic ischemia-reperfusion injury. World J Hepatol 2022; 14(3): 504-515 |
| URL |
https://www.wjgnet.com/1948-5182/full/v14/i3/504.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v14.i3.504 |
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