Publication Name	World Journal of Orthopedics
Manuscript ID	66851
Country	United States

Received	2021-04-07 16:56
Peer-Review Started	2021-04-07 16:57
To Make the First Decision
Return for Revision	2021-10-17 05:15
Revised	2021-11-30 10:02
Second Decision	2022-02-28 05:44
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-03-07 00:12
Articles in Press	2022-03-07 00:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-04-01 11:10
Publish the Manuscript Online	2022-04-12 07:26

ISSN	2218-5836 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Orthopedics
Manuscript Type	Review
Article Title	Antibiotic-free antimicrobial poly (methyl methacrylate) bone cements: A state-of-the-art review
Manuscript Source	Invited Manuscript
All Author List	Gladius Lewis
ORCID	Author(s) ORCID Number Gladius Lewis http://orcid.org/0000-0002-4175-5093
Funding Agency and Grant Number
Corresponding Author	Gladius Lewis, PhD, Full Professor, Department of Mechanical Engineering, Lewis, G (reprint author), Univ Memphis, 316 Engn Sci Bldg, Memphis, TN 38152 USA., The University of Memphis, Department of Mechanical Engineering, The University of Memphis, Tennessee 38152-6576, USA. glewis@memphis.edu, MEMPHIS, TN 38152, United States. glewis@memphis.edu
Key Words	Periprosthetic joint infection; Poly (methyl methacrylate) bone cement; Antibiotic-loaded poly (methyl methacrylate) bone cement bone cement; Antibiotic-free antimicrobial poly (methyl methacrylate) bone cement bone cement
Core Tip	Although antibiotic-loaded poly (methyl methacrylate) (PMMA) bone cements are widely used both as prophylactic agent and in the treatment/management of prosthetic joint infection, there is dissatisfaction about the material. A new generation of antibiotic-free antimicrobial PMMA bone cements (AFAMBCs) is emerging. The present review is a critical appraisal of the literature on AFAMBCs, highlighting its strengths, shortcomings, and possible areas for future studies. The conclusion is that state-of-the-art on AFAMBC formulations is such that it is premature to comment on the potential of any of the formulations for clinical application.
Publish Date	2022-04-12 07:26
Citation	Lewis G. Antibiotic-free antimicrobial poly (methyl methacrylate) bone cements: A state-of-the-art review. World J Orthop 2022; 13(4): 339-353
URL	https://www.wjgnet.com/2218-5836/full/v13/i4/339.htm
DOI	https://dx.doi.org/10.5312/wjo.v13.i4.339

Full Article (PDF)	WJO-13-339.pdf
Full Article (Word)	WJO-13-339.docx
Manuscript File	66851_Auto_Edited.docx
Answering Reviewers	66851-Answering reviewers.zip
Audio Core Tip	66851-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	66851-Conflict-of-interest statement.pdf
Copyright License Agreement	66851-Copyright license agreement.pdf
Peer-review Report	66851-Peer-review(s).pdf
Scientific Misconduct Check	66851-Bing-Wang LL-2.png
Scientific Editor Work List	66851-Scientific editor work list.pdf