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Articles Published Processes
12/24/2021 9:38:39 AM | Browse: 460 | Download: 883
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Received |
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2021-04-27 07:10 |
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Peer-Review Started |
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2021-04-28 12:13 |
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To Make the First Decision |
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Return for Revision |
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2021-06-16 04:46 |
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Revised |
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2021-06-22 14:48 |
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Second Decision |
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2021-11-25 05:35 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-11-28 07:50 |
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Articles in Press |
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2021-11-28 07:50 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-12-15 16:22 |
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Publish the Manuscript Online |
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2021-12-24 09:38 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
Liver regeneration biology: Implications for liver tumour therapies
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Christopher Hadjittofi, Michael Feretis, Jack Martin, Simon Harper and Emmanuel Huguet |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Emmanuel Huguet, BSc, DPhil, FRCS, MBChB, Surgeon, Surgical Oncologist, University Department of Surgery, Addenbrookes Hospital, NIHR Comprehensive Biomedical Research and Academic Health Sciences Center, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB2 0QQ, United Kingdom. emmanuel.huguet@addenbrookes.nhs.uk |
| Key Words |
Liver; Liver regeneration potential; Regeneration biology; Tumour; Therapies |
| Core Tip |
The liver has remarkable regenerative potential, allowing recovery from 90% hepatectomy in some rodent models. Current understanding of liver regeneration comes from in vitro and animal models. Liver regeneration is controlled by mitogens acting in autocrine, paracrine, and endocrine ways. Complex cross talk occurs between parenchymal and non-parenchymal cells. Regeneration involves hypertrophy and hyperplasia, with both cellular phenotypic fidelity and transdifferentiation, which come into play according to the nature and magnitude of the injury, and the presence of underlying liver disease. Current knowledge provides guiding principles for strategies to optimise liver regeneration potential in the treatment of liver tumours. |
| Publish Date |
2021-12-24 09:38 |
| Citation |
Hadjittofi C, Feretis M, Martin J, Harper S, Huguet E. Liver regeneration biology: Implications for liver tumour therapies. World J Clin Oncol 2021; 12(12): 1101-1156 |
| URL |
https://www.wjgnet.com/2218-4333/full/v12/i12/1101.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v12.i12.1101 |
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