Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	67697
Country	Japan

Received	2021-04-29 10:40
Peer-Review Started	2021-04-29 10:42
To Make the First Decision
Return for Revision	2021-06-06 04:11
Revised	2021-06-19 17:09
Second Decision	2021-11-22 03:33
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-11-25 02:24
Articles in Press	2021-11-25 02:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-12-31 06:43
Publish the Manuscript Online	2022-01-11 00:11

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Statin as a therapeutic agent in gastroenterological cancer
Manuscript Source	Invited Manuscript
All Author List	Norio Uemura, Hiromitsu Hayashi and Hideo Baba
ORCID	Author(s) ORCID Number Norio Uemura http://orcid.org/0000-0003-3192-4153 Hiromitsu Hayashi http://orcid.org/0000-0002-1832-4287 Hideo Baba http://orcid.org/0000-0002-6982-3457
Funding Agency and Grant Number
Corresponding Author	Hiromitsu Hayashi, FACS, MD, PhD, Surgeon, Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan. hhayasi@kumamoto-u.ac.jp
Key Words	Statin; HMG CoA reductase inhibitor; Mevalonate pathway; Cancer
Core Tip	Novel pharmacological therapies for cancer are in development, but the expense of new drug development has increased medical costs and placed a heavy financial burden on governments worldwide. Therefore, drug repositioning has become a major focus for new drug development because of reliability and cost effectiveness. Statins are one of the most studied drugs with potential drug repositioning for cancer treatment, but they have not reached clinical application. This review summarizes the results of recent research and clinical studies of statins in cancer, suggests strategies for clinical trial planning, and discusses the potential clinical application of statins for cancer treatment.
Publish Date	2022-01-11 00:11
Citation	Uemura N, Hayashi H, Baba H. Statin as a therapeutic agent in gastroenterological cancer. World J Gastrointest Oncol 2022; 14(1): 110-123
URL	https://www.wjgnet.com/1948-5204/full/v14/i1/110.htm
DOI	https://dx.doi.org/10.4251/wjgo.v14.i1.110

Full Article (PDF)	WJGO-14-110.pdf
Full Article (Word)	WJGO-14-110.docx
Manuscript File	67697_Auto_Edited-A.docx
Answering Reviewers	67697-Answering reviewers.pdf
Audio Core Tip	67697-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	67697-Conflict-of-interest statement.pdf
Copyright License Agreement	67697-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	67697-Language certificate.pdf
Peer-review Report	67697-Peer-review(s).pdf
Scientific Misconduct Check	67697-Bing-Liu M-2.png
Scientific Editor Work List	67697-Scientific editor work list.pdf
CrossCheck Report	67697-CrossCheck report.pdf