Publication Name	World Journal of Psychiatry
Manuscript ID	67829
Country	Canada

Received	2021-05-03 12:38
Peer-Review Started	2021-05-03 12:41
To Make the First Decision
Return for Revision	2021-06-17 04:51
Revised	2021-06-27 16:13
Second Decision	2021-09-02 02:50
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-09-02 05:19
Articles in Press	2021-09-02 05:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-10-13 06:50
Publish the Manuscript Online	2021-10-15 09:56

ISSN	2220-3206 (online)
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Category	Neurosciences
Manuscript Type	Frontier
Article Title	Framework for internal sensation of pleasure using constraints from disparate findings in nucleus accumbens
Manuscript Source	Invited Manuscript
All Author List	Kunjumon Ittira Vadakkan
ORCID	Author(s) ORCID Number Kunjumon Ittira Vadakkan http://orcid.org/0000-0002-2721-6931
Funding Agency and Grant Number
Corresponding Author	Kunjumon Ittira Vadakkan, MBBS, MD, MSc, PhD, Senior Scientist, Division of Neuroscience, Neurosearch Center, 167 Brunswick Street, Toronto M5S2M3, Ontario, Canada. kunjumon.vadakkan@utoronto.ca
Key Words	Pleasure; Internal sensation; Mind; Memory; Long-term potentiation; Long-term depression; Nucleus accumbens; Drug addiction
Core Tip	Pleasure has been studied by examining animal behaviour and its correlations with molecular and electrophysiological changes. Drugs of abuse generate pleasure along with several seemingly unrelated changes in nucleus accumbens (NAc). When pleasure was examined as a first-person inner sensation, it was possible to arrive at a framework of a causal mechanism for its generation that can also provide inter-connected mechanistic explanations for long-term depression (LTD) in NAc in naïve animals, impaired ability to induce LTD in addicted state, attenuation of postsynaptic potentials by both cocaine and dopamine, and reduced firing of medium spiny neurons in NAc by dopamine. Findings made by this work are testable.
Publish Date	2021-10-15 09:56
Citation	Vadakkan KI. Framework for internal sensation of pleasure using constraints from disparate findings in nucleus accumbens. World J Psychiatr 2021; 11(10): 681-695
URL	https://www.wjgnet.com/2220-3206/full/v11/i10/681.htm
DOI	https://dx.doi.org/10.5498/wjp.v11.i10.681

Full Article (PDF)	WJP-11-681.pdf
Full Article (Word)	WJP-11-681.docx
Manuscript File	67829_Auto_Edited-JPY.docx
Answering Reviewers	67829-Answering reviewers.pdf
Audio Core Tip	67829-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	67829-Conflict-of-interest statement.pdf
Copyright License Agreement	67829-Copyright license agreement.pdf
Peer-review Report	67829-Peer-review(s).pdf
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Scientific Misconduct Check	67829-Scientific misconduct check.pdf
Scientific Editor Work List	67829-Scientific editor work list.pdf
CrossCheck Report	67829-CrossCheck report.pdf
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