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Articles Published Processes
4/21/2022 11:35:29 AM | Browse: 370 | Download: 848
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Received |
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2021-05-10 15:26 |
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Peer-Review Started |
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2021-05-20 08:40 |
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To Make the First Decision |
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Return for Revision |
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2021-07-20 04:01 |
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Revised |
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2021-08-08 15:40 |
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Second Decision |
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2022-02-28 05:44 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-03-06 22:15 |
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Articles in Press |
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2022-03-06 22:15 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-04-06 12:10 |
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Publish the Manuscript Online |
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2022-04-21 11:35 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Role of zonula occludens in gastrointestinal and liver cancers
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Amit Kumar Ram and Balasubramaniyan Vairappan |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| JIPMER intramural research grant, Indian Council of Medical Research (ICMR), New Delhi, India |
3/1/3 J.R.F.-2016/LS/HRD |
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| Corresponding Author |
Balasubramaniyan Vairappan, PhD, Additional Professor, Liver Diseases Research Lab, Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Dhanvantri Nagar, Pondicherry 605006, India. balasubramaniyan.v@jipmer.edu.in |
| Key Words |
Tight junction; Zonula occludens-1; Zonula occludens-1 associated nucleic acid binding protein; Hepatocellular carcinoma; Colon cancer; Gastric cancer |
| Core Tip |
Zonula occludens (ZO) proteins (ZO-1, -2, -3) are primarily involved in tight junction formation. Additionally, ZO proteins regulate cell proliferation by interacting with various transcription factors among which ZO/ZO-1 associated nucleic acid-binding protein pathway is of particular importance. Reduced expression of ZO proteins are correlated with poor prognosis in gastrointestinal cancer and hepatocellular carcinoma. Modulating ZO proteins expression with polyphenols, probiotics and peptides represent promising therapeutic agents for cancer treatment. |
| Publish Date |
2022-04-21 11:35 |
| Citation |
Ram AK, Vairappan B. Role of zonula occludens in gastrointestinal and liver cancers. World J Clin Cases 2022; 10(12): 3647-3661 |
| URL |
https://www.wjgnet.com/2307-8960/full/v10/i12/3647.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v10.i12.3647 |
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