Publication Name	World Journal of Clinical Cases
Manuscript ID	68280
Country	China

Received	2021-06-10 01:10
Peer-Review Started	2021-06-10 01:10
To Make the First Decision
Return for Revision	2021-07-05 01:17
Revised	2021-07-10 03:03
Second Decision	2021-08-16 03:29
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-08-16 06:56
Articles in Press	2021-08-16 06:56
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-08-27 05:50
Typeset the Manuscript	2021-09-17 01:40
Publish the Manuscript Online	2021-09-28 10:00

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Obstetrics & Gynecology
Manuscript Type	Case Control Study
Article Title	Pregnancy complications effect on the nickel content in maternal blood, placenta blood and umbilical cord blood during pregnancy
Manuscript Source	Unsolicited Manuscript
All Author List	Ai-Ling Ding, Hong Hu, Fan-Ping Xu, Ling-Yan Liu, Juan Peng and Xu-Dong Dong
ORCID	Author(s) ORCID Number Ai-Ling Ding http://orcid.org/0000-0002-8836-3791 Hong Hu http://orcid.org/0000-0001-8015-8470 Fan-Ping Xu http://orcid.org/0000-0002-9674-0892 Ling-Yan Liu http://orcid.org/0000-0001-8266-3980 Juan Peng http://orcid.org/0000-0003-4976-9147 Xu-Dong Dong http://orcid.org/0000-0003-2013-9723
Funding Agency and Grant Number	Funding Agency Grant Number Yunnan Provincial Health Committee Senior Talent Project L-2018006 Yunnan Provincial Health Committee Senior Talent Project H-2018045 International Science and Technology Cooperation Special Key Research and Development Plan 2017IB004 Academician Expert Workstation of Yunnan Province 202005AF150033
Corresponding Author	Xu-Dong Dong, MD, Director, Director, The Obstetrical Department, The First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, No. 157 Jinbi Road, Xishan District, Kunming 650032, Yunnan Province, China. dxdmail@sohu.com
Key Words	Heavy metal; Nickel; Gestational diabetes mellitus; Hypertensive disorder complicating pregnancy; Placental barrier; Newborn
Core Tip	This study aimed to distribution of nickel (Ni) in the maternal-fetal system and placental barrier function are described, and the effect of Ni exposure on fetal health in mothers with pregnancy complications was investigated. The results suggest that in the maternal-fetal system of women with pregnancy complications, the barrier effect of the placenta against Ni is weakened, thus affecting healthy growth of the fetus in the uterus. This study indicated that more attention should be focused on reducing Ni environmental exposure during pregnancy and improving the quality of the living environment in order to ensure normal development of the fetus.
Publish Date	2021-09-28 10:00
Citation	Ding AL, Hu H, Xu FP, Liu LY, Peng J, Dong XD. Pregnancy complications effect on the nickel content in maternal blood, placenta blood and umbilical cord blood during pregnancy. World J Clin Cases 2021; 9(28): 8340-8348
URL	https://www.wjgnet.com/2307-8960/full/v9/i28/8340.htm
DOI	https://dx.doi.org/10.12998/wjcc.v9.i28.8340

Full Article (PDF)	WJCC-9-8340.pdf
Full Article (Word)	WJCC-9-8340.docx
STROBE Statement	68280-STROBE-Statement-revision.pdf
Manuscript File	68280-Review-FilipodiaCL.docx
Answering Reviewers	68280-Answering reviewers.pdf
Audio Core Tip	68280-Audio core tip.m4a
Biostatistics Review Certificate	68280-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	68280-Conflict-of-interest statement.pdf
Copyright License Agreement	68280-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	68280-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	68280-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	68280-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	68280-Language certificate.pdf
Journal Editor-in-Chief Review Report	68280-Peer-review(s).pdf
Scientific Misconduct Check	68280-Scientific misconduct check.pdf
Scientific Editor Work List	68280-Scientific editor work list.pdf
CrossCheck Report	68280-CrossCheck report.pdf