| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Basic Study |
| Article Title |
Effects of viremia and CD4 recovery on gut “microbiome-immunity” axis in treatment-naïve HIV-1-infected patients undergoing antiretroviral therapy
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Edda Russo, Giulia Nannini, Gaetana Sterrantino, Seble Tekle Kiros, Vincenzo Di Pilato, Marco Coppi, Simone Baldi, Elena Niccolai, Federica Ricci, Matteo Ramazzotti, Marco Pallecchi, Filippo Lagi, Gian Maria Rossolini, Alessandro Bartoloni, Gianluca Bartolucci and Amedeo Amedei |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| University of Florence |
XXXV PhD Program |
|
| Corresponding Author |
Amedeo Amedei, BSc, PhD, Professor, Reader (Associate Professor), Department of Clinical and Experimental Medicine, University of Florence, Viale Pieraccini, 6, Florence 50139, Tuscany, Italy. aamedei@unifi.it |
| Key Words |
HIV; Antiretroviral therapy; Microbiome-immunity axis; Microbiota; Cytokines; Short chain fatty acid; Inflammation; Immunological responders; Viremia |
| Core Tip |
Even in patients receiving effective antiretroviral therapy (ART), HIV-1 infection is characterized by persistent systemic inflammation and immune activation. Changes in the gut microbiota can occur with HIV infection and treatment with ART; however, the data are still conflicting. For these reasons, we compared the fecal microbial composition and serum cytokine profile of treatment-naïve patients before starting ART and after virological suppression. Finally, we evaluated the microbiota composition, microbial metabolites, and cytokine profile of patients with CD4/CD8 ratio < 1 and CD4/CD8 > 1 (immunological responders). |
| Publish Date |
2022-02-09 07:25 |
| Citation |
Russo E, Nannini G, Sterrantino G, Kiros ST, Pilato VD, Coppi M, Baldi S, Niccolai E, Ricci F, Ramazzotti M, Pallecchi M, Lagi F, Rossolini GM, Bartoloni A, Bartolucci G, Amedei A. Effects of viremia and CD4 recovery on gut “microbiome-immunity” axis in treatment-naïve HIV-1-infected patients undergoing antiretroviral therapy. World J Gastroenterol 2022; 28(6): 635-652 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i6/635.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i6.635 |
