Publication Name	World Journal of Gastroenterology
Manuscript ID	6898
Country	Hungary

Received	2013-10-29 20:04
Peer-Review Started	2013-11-01 10:45
To Make the First Decision	2013-12-16 17:31
Return for Revision	2013-12-17 19:42
Revised	2013-12-25 15:01
Second Decision	2014-01-20 18:57
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-01-20 19:29
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-02-18 04:31
Typeset the Manuscript	2014-03-03 10:47
Publish the Manuscript Online	2014-03-12 14:46

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Immune dysfunction in cirrhosis
Manuscript Source	Invited Manuscript
All Author List	Nora Sipeki, Peter Antal-Szalmas, Peter L Lakatos and Maria Papp
Funding Agency and Grant Number	Funding Agency Grant Number Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences Internal Research Grant of University of Debrecen
Corresponding Author	Maria Papp, MD, PhD, Institute of Medicine, Division of Gastroenterology, University of Debrecen, Nagyerdei krt 98, H-4032 Debrecen, Hungary. papp.maria@med.unideb.hu
Key Words	Cirrhosis; Immune dysfunction; Endotoxemia
Core Tip	Innate and adaptive immune dysfunction, also referred to as cirrhosis-associated immune dysfunction syndrome, plays a pivotal role in the pathogenesis of cirrhosis in both acute and chronic disease progression. During progression, acute decompensation is associated with organ failure(s), the so-called acute-on chronic liver failure, and chronic decompensation with progression of liver fibrosis and development of disease specific complications comprise distinct clinical entities with different immunopathology mechanisms. Enhanced bacterial translocation associated with systemic endotoxemia and systemic bacterial infections have substantial impacts in both clinical situations. In this review the authors provide overview of immune dysfunction and its consequences in cirrhosis.
Publish Date	2014-03-12 14:46
Citation	Sipeki N, Antal-Szalmas P, Lakatos PL, Papp M. Immune dysfunction in cirrhosis. World J Gastroenterol 2014; 20(10): 2564-2577
URL	http://www.wjgnet.com/1007-9327/full/v20/i10/2564.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i10.2564

Full Article (PDF)	WJG-20-2564.pdf
Full Article (Word)	WJG-20-2564.doc
Manuscript File	6898-Review.docx
Answering Reviewers	6898-Answering review.pdf
Copyright License Agreement	6898-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	6898-Language certificate.pdf
Peer-review Report	6898-Peer review(s).pdf
Scientific Editor Work List	6898-Scientific editor work list.doc