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11/6/2021 4:43:07 AM | Browse: 416 | Download: 707
Publication Name World Journal of Gastroenterology
Manuscript ID 69501
Country/Territory Japan
Received
2021-07-04 06:41
Peer-Review Started
2021-07-04 06:46
To Make the First Decision
Return for Revision
2021-07-14 00:02
Revised
2021-07-27 13:33
Second Decision
2021-08-31 03:34
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-08-31 10:15
Articles in Press
2021-08-31 10:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
2021-09-11 20:08
Typeset the Manuscript
2021-11-02 01:16
Publish the Manuscript Online
2021-11-06 04:43
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Retrospective Study
Article Title Clinical characteristics of gastrointestinal immune-related adverse events of immune checkpoint inhibitors and their association with survival
Manuscript Source Unsolicited Manuscript
All Author List Kentaro Yamada, Tsunaki Sawada, Masanao Nakamura, Takeshi Yamamura, Keiko Maeda, Eri Ishikawa, Tadashi Iida, Yasuyuki Mizutani, Naomi Kakushima, Takuya Ishikawa, Kazuhiro Furukawa, Eizaburo Ohno, Takashi Honda, Hiroki Kawashima, Masatoshi Ishigami, Satoshi Furune, Tetsunari Hase, Kenji Yokota, Osamu Maeda, Naozumi Hashimoto, Masashi Akiyama, Yuichi Ando and Mitsuhiro Fujishiro
ORCID
Author(s) ORCID Number
Kentaro Yamada http://orcid.org/0000-0002-0657-1790
Tsunaki Sawada http://orcid.org/0000-0002-4779-9708
Masanao Nakamura http://orcid.org/0000-0002-5444-143X
Takeshi Yamamura http://orcid.org/0000-0003-4994-016X
Keiko Maeda http://orcid.org/0000-0001-7615-0476
Eri Ishikawa http://orcid.org/0000-0003-1623-7996
Tadashi Iida http://orcid.org/0000-0001-5491-6012
Yasuyuki Mizutani http://orcid.org/0000-0002-4363-3161
Naomi Kakushima http://orcid.org/0000-0002-9635-2099
Takuya Ishikawa http://orcid.org/0000-0001-5814-3555
Kazuhiro Furukawa http://orcid.org/0000-0003-0980-9095
Eizaburo Ohno http://orcid.org/0000-0002-7730-4630
Takashi Honda http://orcid.org/0000-0001-8951-0952
Hiroki Kawashima http://orcid.org/0000-0002-3720-781X
Masatoshi Ishigami http://orcid.org/0000-0003-0938-631X
Satoshi Furune http://orcid.org/0000-0003-1457-3996
Tetsunari Hase http://orcid.org/0000-0002-9653-8424
Kenji Yokota http://orcid.org/0000-0002-0000-1746
Osamu Maeda http://orcid.org/0000-0003-4700-6541
Naozumi Hashimoto http://orcid.org/0000-0003-2337-629X
Masashi Akiyama http://orcid.org/0000-0001-5863-9315
Yuichi Ando http://orcid.org/0000-0002-6849-2297
Mitsuhiro Fujishiro http://orcid.org/0000-0002-4074-1140
Funding Agency and Grant Number
Corresponding Author Tsunaki Sawada, PhD, Assistant Professor, Department of Endoscopy, Nagoya University Hospital, 65 Tsurumai-cho, Showa-ku, Nagoya City 4668560, Aichi, Japan. t.sawada@med.nagoya-u.ac.jp
Key Words Colitis; Cytotoxic T-lymphocyte antigen 4; Diarrhea; Drug-related side effects and adverse reactions; Immune checkpoint inhibitors; Prognosis
Core Tip We compared the clinical characteristics of gastrointestinal immune-related adverse events (GI-irAEs) in patients receiving anti-programmed cell death-1/programmed death-ligand 1 (anti-PD-1/PD-L1), anti-cytotoxic T-lymphocyte antigen 4 (CTLA-4), or a combination of anti-PD-1 and anti-CTLA-4 antibodies. We also examined the correlation between GI-irAE development and the prognosis of patients with non-small cell lung cancer (LC) and malignant melanoma (MM). GI-irAEs occurred more frequently and with higher severity in patients receiving anti-CTLA-4 antibodies than in those receiving anti-PD-1/PD-L1 antibodies. Patients with MM, but not non-small cell LC, who continued immune checkpoint inhibitor treatment after developing GI-irAEs had better overall survival.
Publish Date 2021-11-06 04:43
Citation Yamada K, Sawada T, Nakamura M, Yamamura T, Maeda K, Ishikawa E, Iida T, Mizutani Y, Kakushima N, Ishikawa T, Furukawa K, Ohno E, Honda T, Kawashima H, Ishigami M, Furune S, Hase T, Yokota K, Maeda O, Hashimoto N, Akiyama M, Ando Y, Fujishiro M. Clinical characteristics of gastrointestinal immune-related adverse events of immune checkpoint inhibitors and their association with survival. World J Gastroenterol 2021; 27(41): 7190-7206
URL https://www.wjgnet.com/1007-9327/full/v27/i41/7190.htm
DOI https://dx.doi.org/10.3748/wjg.v27.i41.7190
Full Article (PDF) WJG-27-7190.pdf
Full Article (Word) WJG-27-7190.docx
Manuscript File 69501-Review-Filipodia.docx
Answering Reviewers 69501-Answering reviewers.pdf
Audio Core Tip 69501-Audio core tip.mp3
Biostatistics Review Certificate 69501-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 69501-Conflict-of-interest statement.pdf
Copyright License Agreement 69501-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 69501-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 69501-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 69501-Language certificate.pdf
Peer-review Report 69501-Peer-review(s).pdf
Scientific Misconduct Check 69501-Scientific misconduct check.pdf
Scientific Editor Work List 69501-Scientific editor work list.pdf