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Articles Published Processes
10/26/2021 3:59:25 AM | Browse: 356 | Download: 779
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Received |
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2021-07-06 07:32 |
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Peer-Review Started |
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2021-07-06 07:34 |
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To Make the First Decision |
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Return for Revision |
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2021-07-29 00:46 |
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Revised |
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2021-08-02 03:26 |
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Second Decision |
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2021-09-13 02:26 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-09-17 00:18 |
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Articles in Press |
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2021-09-17 00:18 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-10-22 09:03 |
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Publish the Manuscript Online |
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2021-10-26 03:59 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Engineering, Biomedical |
| Manuscript Type |
Minireviews |
| Article Title |
Current knowledge on the multiform reconstitution of intestinal stem cell niche
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zi-Yan Xu, Jin-Jian Huang, Ye Liu, Yun Zhao, Xiu-Wen Wu and Jian-An Ren |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| 333 High Level Talents Training Project of Jiangsu Province |
BRA2019011f |
| Project of Military Research |
CLB19J025 |
| Project of Military Research |
TGKS2019002 |
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| Corresponding Author |
Jian-An Ren, FACS, MD, PhD, Chief Doctor, Professor, Surgeon, Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, No. 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, China. jiananr@gmail.com |
| Key Words |
Intestinal organoids; Reconstitution; Stem cell niche; Bioengineering; Hydrogel |
| Core Tip |
Organoid technique results in a high-performance, self-assembling and physiological platform in intestinal research and therapy. Despite the promising prospect of organoids research, their expanding applications are hampered by the canonical culture pattern, which reveals limitations such as inaccessible lumen, confine scale, batch to batch variation and low reproducibility. The tumor-origin of Matrigel also raises biosafety concerns in clinical treatment. The convergence of breakthroughs in cellular biology and bioengineering contribute to the development of biomaterial-based matrix or bioink for intestinal stem cells and incorporation of 3D printing and organ-on-a-chip technique, which may further advance organoid in future pathophysiological studies or functional tissue reconstitution. |
| Publish Date |
2021-10-26 03:59 |
| Citation |
Xu ZY, Huang JJ, Liu Y, Zhao Y, Wu XW, Ren JA. Current knowledge on the multiform reconstitution of intestinal stem cell niche. World J Stem Cells 2021; 13(10): 1564-1579 |
| URL |
https://www.wjgnet.com/1948-0210/full/v13/i10/1564.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v13.i10.1564 |
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