Publication Name	World Journal of Clinical Cases
Manuscript ID	70331
Country	China

Received	2021-07-30 16:29
Peer-Review Started	2021-07-30 16:31
To Make the First Decision
Return for Revision	2021-12-01 09:17
Revised	2021-12-11 16:11
Second Decision	2022-03-18 06:12
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-03-26 22:03
Articles in Press	2022-03-26 22:03
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-03-15 16:27
Typeset the Manuscript	2022-04-14 03:28
Publish the Manuscript Online	2022-05-13 08:46

ISSN	2307-8960 (online)
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Category	Dermatology
Manuscript Type	Case Report
Article Title	Mixed porokeratosis with a novel mevalonate kinase gene mutation: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Hong-Jun Xu and Guang-Dong Wen
ORCID	Author(s) ORCID Number Hong-Jun Xu http://orcid.org/0000-0002-4002-1549 Guang-Dong Wen http://orcid.org/0000-0002-9221-7033
Funding Agency and Grant Number
Corresponding Author	Hong-Jun Xu, MD, Chief Doctor, Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, 95 Yong'an Road, Xicheng, Beijing 100050, P.R. China, Beijing 100050, China. ink-008@163.com
Key Words	Disseminated superficial actinic porokeratosis; Porokeratosis ptychotropica; Mevalonate kinase gene; Gene mutation; Microwave knife; Case report
Core Tip	Porokeratosis is a rare, acquired, or inherited disorder of keratinization. The coexistence of disseminated superficial actinic porokeratosis (DSAP) and porokeratosis ptychotropica (Ppt) is rare. We present an unusual case of DSAP coexisting with Ppt and identified a novel mevalonate kinase (MVK) gene mutation in this patient’s family. To date, only four cases of DSAP coexisting with Ppt have been reported in the English literature. One case also had an MVK gene mutation. Thus, mutation of phosphomevalonate kinase pathway genes, especially the MVK gene, may have an important role in the pathogenesis of DSAP coexisting with Ppt.
Publish Date	2022-05-13 08:46
Citation	Xu HJ, Wen GD. Mixed porokeratosis with a novel mevalonate kinase gene mutation: A case report. World J Clin Cases 2022; 10(14): 4528-4534
URL	https://www.wjgnet.com/2307-8960/full/v10/i14/4528.htm
DOI	https://dx.doi.org/10.12998/wjcc.v10.i14.4528

Full Article (PDF)	WJCC-10-4528.pdf
Full Article (Word)	WJCC-10-4528.docx
CARE Checklist–2016	70331-CARE-Checklist–2016-revision.pdf
Manuscript File	70331_Auto_Edited-LJH-Webster J.docx
Answering Reviewers	70331-Answering reviewers.pdf
Audio Core Tip	70331-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	70331-Conflict-of-interest statement.pdf
Copyright License Agreement	70331-Copyright license agreement.pdf
Signed Consent for Treatment Form(s) or Document(s)	70331-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	70331-Language certificate.pdf
Peer-review Report	70331-Peer-review(s).pdf
Scientific Misconduct Check	70331-Bing-Liu JH-2.jpg
Scientific Misconduct Check	70331-CrossCheck.jpg
Scientific Editor Work List	70331-Scientific editor work list.pdf
CrossCheck Report	70331-CrossCheck report.pdf