Publication Name	World Journal of Clinical Cases
Manuscript ID	70630
Country	China

Received	2021-08-09 06:46
Peer-Review Started	2021-08-09 06:49
To Make the First Decision
Return for Revision	2021-11-06 07:50
Revised	2021-11-23 09:04
Second Decision	2022-02-25 06:33
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-02-27 19:49
Articles in Press	2022-02-27 19:49
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-02-09 17:43
Typeset the Manuscript	2022-03-14 04:43
Publish the Manuscript Online	2022-04-08 12:06

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Pediatrics
Manuscript Type	Case Report
Article Title	Young children with multidrug-resistant epilepsy and vagus nerve stimulation responding to perampanel: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Hua Yang and Dan Yu
ORCID	Author(s) ORCID Number Hua Yang http://orcid.org/0000-0001-5418-3605 Dan Yu http://orcid.org/0000-0003-2859-5897
Funding Agency and Grant Number
Corresponding Author	Dan Yu, MD, Doctor, Professor, Department of Pediatrics, West China Second University Hospital, Sichuan University, No. 20, Section 3, South Renmin Road, Chengdu 610041, Sichuan Province, China. yudan540@163.com
Key Words	Perampanel; Young children; Drug-resistant epilepsy; Vagus nerve stimulation; Case report
Core Tip	We report a 4-year-old boy with multidrug-resistant epilepsy who still had frequent seizures after vagus nerve stimulation (VNS) implantation, and he showed significant response to perampanel (PER) as add-on in a dose-dependent manner. Considering its favorable cognitive profile and the similar efficacy and safety profile of PER in children aged < 12 years as in older people, we proposed that the use of PER as add-on could further reduce the seizure frequency for young children with drug-resistant epilepsy and even after VNS implantation, which may be attributed to its novel antiepileptic mechanism.
Publish Date	2022-04-08 12:06
Citation	Yang H, Yu D. Young children with multidrug-resistant epilepsy and vagus nerve stimulation responding to perampanel: A case report. World J Clin Cases 2022; 10(11): 3511-3517
URL	https://www.wjgnet.com/2307-8960/full/v10/i11/3511.htm
DOI	https://dx.doi.org/10.12998/wjcc.v10.i11.3511

Full Article (PDF)	WJCC-10-3511.pdf
Full Article (Word)	WJCC-10-3511.docx
CARE Checklist–2016	70630-CARE-Checklist–2016-revision.pdf
Manuscript File	70630_Auto_Edited-JJW-Kerr C.docx
Answering Reviewers	70630-Answering reviewers.pdf
Audio Core Tip	70630-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	70630-Conflict-of-interest statement.pdf
Copyright License Agreement	70630-Copyright license agreement.pdf
Signed Consent for Treatment Form(s) or Document(s)	70630-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	70630-Language certificate.pdf
Supplementary Material	70630-Supplementary material.pdf
Peer-review Report	70630-Peer-review(s).pdf
Scientific Misconduct Check	70630-Bing-Wang JJ-2.png
Scientific Editor Work List	70630-Scientific editor work list.pdf