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Articles Published Processes
3/15/2022 2:23:07 PM | Browse: 419 | Download: 750
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Received |
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2021-09-23 13:19 |
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Peer-Review Started |
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2021-09-23 13:21 |
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To Make the First Decision |
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Return for Revision |
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2021-11-08 04:17 |
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Revised |
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2021-12-24 22:23 |
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Second Decision |
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2022-02-08 05:59 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-02-10 16:31 |
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Articles in Press |
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2022-02-10 16:31 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2022-01-26 11:03 |
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Typeset the Manuscript |
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2022-02-23 08:48 |
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Publish the Manuscript Online |
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2022-03-15 14:23 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Free fatty acids, glucose, and insulin in type 2 diabetes mellitus
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Rob NM Weijers |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Rob NM Weijers, PhD, Teacher, Teaching Hospital, OLVG, Oosterpark 9, 1091 AC Amsterdam 9, Amsterdam 95500, Netherlands. robw01@xs4all.nl |
| Key Words |
Free fatty acids; Membrane flexibility; NKX2-1 gene; RNA sequencing; Type 2 diabetes; TPD52L-3 gene; Unsaturation index |
| Core Tip |
A substantial reduction in both NKX2-1 and TPD52L3 proteins is largely responsible for a reduction in carbon-carbon double bonds of phospholipids which, in turn, translates into the redistribution of the lateral pressure profile, and thereby reduces the transport speed of glucose molecules across the cell membrane. Consequently, the amount of plasma glucose entering the β-cell via GLUT2 gives a false negative result. Also the redistribution of the lateral pressure profile lowers the insulin release from β-cells into the blood circulation. Both phenomena cause the onset of type 2 diabetes mellitus. |
| Publish Date |
2022-03-15 14:23 |
| Citation |
Weijers RN. Free fatty acids, glucose, and insulin in type 2 diabetes mellitus. World J Diabetes 2022; 13(3): 275-277 |
| URL |
https://www.wjgnet.com/1948-9358/full/v13/i3/275.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v13.i3.275 |
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