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Articles Published Processes
7/11/2022 8:36:00 AM | Browse: 227 | Download: 376
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Received |
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2022-01-17 13:15 |
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Peer-Review Started |
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2022-01-17 13:16 |
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To Make the First Decision |
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Return for Revision |
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2022-03-16 01:05 |
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Revised |
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2022-03-24 14:23 |
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Second Decision |
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2022-06-01 02:58 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2022-06-03 21:16 |
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Articles in Press |
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2022-06-03 21:16 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-07-05 02:56 |
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Publish the Manuscript Online |
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2022-07-11 08:36 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Dermatology |
| Manuscript Type |
Clinical and Translational Research |
| Article Title |
Molecular mechanisms of Biyu decoction as treatment for psoriasis: A network pharmacology and molecular docking study
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zi Wang, Hao-Min Zhang, Yuan-Rui Guo and Ling-Ling Li |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81874393 |
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| Corresponding Author |
Ling-Ling Li, PhD, Doctor, Department of Dermatology, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, No. 5 Haiyuncang Road, Dongcheng District, Beijing 100700, China. linglingli1980@163.com |
| Key Words |
Medicine; Chinese traditional; Molecular docking simulation; Protein interaction maps; Psoriasis; Gene ontology; Network pharmacology |
| Core Tip |
Biyu decoction has significant effects on psoriasis; however, its molecular targets in psoriasis remain unknown. We conducted a network pharmacology and molecular docking study to determine whether Biyu decoction ingredients target molecules and signaling pathways related to psoriasis pathogenesis. The main active ingredients identified include quercetin, kaempferol, beta-sitosterol, naringenin, and acetyl-shikonin. Target genes included MAPK3, JUN, FOS, MYC, MAPK8, STAT3, and NFKBIA, which can regulate the inflammatory state mediated by psoriasis immune cells and mediate the expression of factors that adjust local skin inflammation. Our results confirm that Biyu decoction can treat psoriasis through multi-component, multi-target, and multi-channel synergy. |
| Publish Date |
2022-07-11 08:36 |
| Citation |
Wang Z, Zhang HM, Guo YR, Li LL. Molecular mechanisms of Biyu decoction as treatment for psoriasis: A network pharmacology and molecular docking study. World J Clin Cases 2022; 10(21): 7224-7241 |
| URL |
https://www.wjgnet.com/2307-8960/full/v10/i21/7224.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v10.i21.7224 |
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