Publication Name	World Journal of Clinical Cases
Manuscript ID	75675
Country	China

Received	2022-02-11 08:34
Peer-Review Started	2022-02-11 08:34
To Make the First Decision
Return for Revision	2022-04-13 09:51
Revised	2022-04-27 17:52
Second Decision	2022-06-06 03:23
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-06-17 22:17
Articles in Press	2022-06-17 22:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-07-13 02:43
Publish the Manuscript Online	2022-07-22 07:03

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Clinical Neurology
Manuscript Type	Retrospective Study
Article Title	Application of metagenomic next-generation sequencing in the diagnosis of infectious diseases of the central nervous system after empirical treatment
Manuscript Source	Unsolicited Manuscript
All Author List	Ying-Ying Chen, Yan Guo, Xin-Hong Xue and Pang Feng
ORCID	Author(s) ORCID Number Ying-Ying Chen http://orcid.org/000-0003-0777-9224 Yan Guo http://orcid.org/0000-0002-0668-4285
Funding Agency and Grant Number
Corresponding Author	Ying-Ying Chen, PhD, Additional Professor, Department of Neurology, Liaocheng People's Hospital, No. 67 Dongchang West Road, Liaocheng 252000, Shandong Province, China. chen323232azqiqi@163.com
Key Words	Metagenomic next-generation sequencing; Cerebrospinal fluid; Central nervous system infection; Pathogenic culture
Core Tip	The study found that metagenomic next-generation sequencing (mNGS) had a higher sensitivity than the conventional methods in the diagnosis of infectious diseases of the central nervous system after empirical treatment. mNGS has significant clinical value and should be used mainly in early pathogen diagnosis in the future.
Publish Date	2022-07-22 07:03
Citation	Chen YY, Guo Y, Xue XH, Pang F. Application of metagenomic next-generation sequencing in the diagnosis of infectious diseases of the central nervous system after empirical treatment. World J Clin Cases 2022; 10(22): 7760-7771
URL	https://www.wjgnet.com/2307-8960/full/v10/i22/7760.htm
DOI	https://dx.doi.org/10.12998/wjcc.v10.i22.7760

Full Article (PDF)	WJCC-10-7760.pdf
Full Article (Word)	WJCC-10-7760.docx
Manuscript File	75675_Auto_Edited-YJM-LS.docx
Answering Reviewers	75675-Answering reviewers.pdf
Audio Core Tip	75675-Audio core tip.m4a
Biostatistics Review Certificate	75675-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	75675-Conflict-of-interest statement.pdf
Copyright License Agreement	75675-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	75675-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	75675-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	75675-Language certificate.pdf
Peer-review Report	75675-Peer-review(s).pdf
Scientific Editor Work List	75675-Scientific editor work list.pdf
CrossCheck Report	75675-CrossCheck report.pdf