Publication Name	World Journal of Diabetes
Manuscript ID	7681
Country	Brazil

Received	2013-11-30 11:14
Peer-Review Started	2013-11-30 11:58
To Make the First Decision	2014-02-13 16:13
Return for Revision	2014-02-19 21:50
Revised
Second Decision	2014-03-18 14:56
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-03-18 15:15
Articles in Press	2014-05-23 09:17
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-03-27 23:59
Typeset the Manuscript	2014-06-13 21:01
Publish the Manuscript Online	2014-06-16 15:44

ISSN	1948-9358 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Topic Highlights
Article Title	Impact of hypoglycemic agents on myocardial ischemic preconditioning
Manuscript Source	Invited Manuscript
All Author List	Rosa Maria Rahmi Garcia, Paulo Cury Rezende and Whady Hueb
Funding Agency and Grant Number	Funding Agency Grant Number Zerbini Foundation
Corresponding Author	Whady Hueb, MD, PhD, MASS Study Group, Heart Institute of the University of S?o Paulo, Av. Dr. Eneas de Carvalho Aguiar, 44, AB, Sala 114, Cerqueira Cesar, S?o Paulo 05403-000, Brazil. mass@incor.usp.br
Key Words	Ischemic preconditioning; Myocardial ischemia; Coronary artery disease; Hypoglycemic agents; Diabetes mellitus
Core Tip	Ischemic preconditioning (IP) is a complex phenomenon that can be the target of drug activities affecting the ability of the heart to adapt to ischemic stress. The literature contains conflicting results regarding whether the use of hypoglycemic agents interfere on cardiovascular mortality. Findings from studies about the effects of hypoglycemic drugs on IP have implications for diabetic patients, especially for those with high risk of events. Their results infer that myocardium can be benefited or not from the action of such drugs. Thus, therapeutic options go beyond glucose-lowering efficacy and should also ponder possible implications with mechanisms of myocardial protection.
Publish Date	2014-06-16 15:44
Citation	Rahmi Garcia RM, Rezende PC, Hueb W. Impact of hypoglycemic agents on myocardial ischemic preconditioning. World J Diabetes 2014; 5(3): 258-266
URL	http://www.wjgnet.com/1948-9358/full/v5/i3/258.htm
DOI	http://dx.doi.org/10.4239/wjd.v5.i3.258

Full Article (PDF)	WJD-5-258.pdf
Full Article (Word)	WJD-5-258.doc
Manuscript File	7681-Review.docx
Answering Reviewers	7681-Answering reviewers.pdf
Copyright License Agreement	7681-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	7681-Language certificate.pdf
Peer-review Report	7681-Peer review(s).pdf
Scientific Editor Work List	7681-Scientific editor work list.doc