Publication Name	World Journal of Clinical Cases
Manuscript ID	77442
Country	China

Received	2022-05-12 04:19
Peer-Review Started	2022-05-10 12:04
To Make the First Decision
Return for Revision	2022-05-30 09:38
Revised	2022-06-05 23:52
Second Decision	2022-06-08 03:12
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-06-17 21:27
Articles in Press	2022-06-17 21:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-06-23 08:32
Publish the Manuscript Online	2022-07-11 08:36

ISSN	2307-8960 (online)
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Category	Oncology
Manuscript Type	Randomized Controlled Trial
Article Title	Comparison of involved-field intensity-modulated radiotherapy combined with S-1 vs radiotherapy alone for elderly patients with esophageal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Li-Hua Liu, Mao-Hui Yan, Yu-Peng Di, Zhi-Guang Fu, Xiao-Dan Zhang and Hong-Qi Li
ORCID	Author(s) ORCID Number Li-Hua Liu http://orcid.org/0000-0003-4351-1823 Mao-Hui Yan http://orcid.org/0000-0002-5106-3533 Yu-Peng Di http://orcid.org/0000-0002-1635-8918 Zhi-Guang Fu http://orcid.org/0000-0002-1916-7447 Hong-Qi Li http://orcid.org/0000-0001-6944-701X
Funding Agency and Grant Number	Funding Agency Grant Number the Youth PhD Advancement Project of Air Force Medical Center, PLA 21ZT01 the Clinical Project of Air Force Medical Center, PLA 2021LC009
Corresponding Author	Hong-Qi Li, MD, Associate Chief Physician, Department of Radiotherapy, Air Force Medical Center, Chinese People’s Liberation Army, No. 30 Fucheng Road, Haidian District, Beijing 100142, China. fmmuli3786@163.com
Key Words	Elderly patients; Esophageal cancer; Involved-field radiation therapy; S-1; Chemotherapy
Core Tip	Esophageal cancer (EC) represents the second most common gastrointestinal cancer in China, there is less evidence on the diagnosis and management of elderly EC patients. It is important to explore how elderly EC patients benefit from radical radiochemotherapy regimens, including the target area of radiotherapy (RT), radiation dose and fraction, and choice of chemotherapy drugs. Compared with involved-field intensity-modulated RT (IF-IMRT) alone, IF-IMRT + S-1 shows the benefits of preventing progressive disease and prolonging survival without increasing adverse reactions. Therefore, this concurrent radiochemotherapy deserves clinical application.
Publish Date	2022-07-11 08:36
Citation	Liu LH, Yan MH, Di YP, Fu ZG, Zhang XD, Li HQ. Comparison of involved-field intensity-modulated radiotherapy combined with S-1 vs radiotherapy alone for elderly patients with esophageal cancer. World J Clin Cases 2022; 10(21): 7365-7375
URL	https://www.wjgnet.com/2307-8960/full/v10/i21/7365.htm
DOI	https://dx.doi.org/10.12998/wjcc.v10.i21.7365

Full Article (PDF)	WJCC-10-7365.pdf
Full Article (Word)	WJCC-10-7365.docx
Manuscript File	77442_Auto_Edited-LS.docx
Answering Reviewers	77442-Answering reviewers.pdf
Audio Core Tip	77442-Audio core tip.m4a
Biostatistics Review Certificate	77442-Biostatistics statement.pdf
Clinical Trial Registration Statement	77442-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	77442-Conflict-of-interest statement.pdf
Copyright License Agreement	77442-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	77442-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	77442-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	77442-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	77442-Language certificate.pdf
Peer-review Report	77442-Peer-review(s).pdf
Scientific Misconduct Check	77442-Bing-Wang JJ-2.png
Scientific Editor Work List	77442-Scientific editor work list.pdf