Publication Name	World Journal of Gastroenterology
Manuscript ID	78447
Country	China

Received	2022-06-28 05:45
Peer-Review Started	2022-06-28 05:49
First Decision by Editorial Office Director	2022-08-19 22:53
Return for Revision	2022-08-19 22:53
Revised	2022-09-07 05:31
Publication Fee Transferred
Second Decision by Editor	2022-09-23 03:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2022-09-23 16:05
Articles in Press	2022-09-23 16:05
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-10-10 00:11
Publish the Manuscript Online	2022-10-18 08:29

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Endocrinology & Metabolism
Manuscript Type	Observational Study
Article Title	Serum metabolic profiling of targeted bile acids reveals potentially novel biomarkers for primary biliary cholangitis and autoimmune hepatitis
Manuscript Source	Unsolicited Manuscript
All Author List	Zhen-Hua Ma, Xiao-Mei Wang, Rui-Hong Wu, Da-Lin Hao, Li-Chao Sun, Pan Li and Jun-Qi Niu
ORCID	Author(s) ORCID Number Xiao-Mei Wang http://orcid.org/0000-0003-2606-4013 Jun-Qi Niu http://orcid.org/0000-0001-5415-2024
Funding Agency and Grant Number	Funding Agency Grant Number Health and Family Planning Commission Project of Jilin Province 2016Q043 Health and Hygiene Committee Project of Jilin Province 2021LC082
Corresponding Author	Jun-Qi Niu, MMed, Professor, Department of Hepatology, The First Hospital of Jilin University, No. 1 Xinmin Dajie, Chaoyang District, Changchun 130061, Jilin Province, China. junqiniu@jlu.edu.cn
Key Words	Primary biliary cholangitis; Autoimmune hepatitis; Biomarkers; Serum metabolic profiling; Bile acids; Ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry
Core Tip	Using full-contour metabolomics and SRM, to determine non-invasive, reliable, and sensitive biochemical markers for the differential diagnosis of primary biliary cholangitis (PBC) and autoimmune hepatitis (AIH). We revealed the increased levels of chenodeoxycholic acid, lithocholic acid (LCA), taurolithocholic acid (TLCA), and LCA + TLCA in the PBC group compared with those in the AIH group. The levels of glycochenodeoxycholic acid, glycochenodeoxycholic sulfate, and taurodeoxycholic acid were gradually elevated with the increase of Child-Pugh class, which was correlated with the severity of disease. The levels of BAs could serve as potential biomarkers for the early diagnosis and assessment of the severity of PBC and AIH.
Publish Date	2022-10-18 08:29
Citation	Ma ZH, Wang XM, Wu RH, Hao DL, Sun LC, Li P, Niu JQ. Serum metabolic profiling of targeted bile acids reveals potentially novel biomarkers for primary biliary cholangitis and autoimmune hepatitis. World J Gastroenterol 2022; 28(39): 5764-5783
URL	https://www.wjgnet.com/1007-9327/full/v28/i39/5764.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i39.5764

Full Article (PDF)	WJG-28-5764.pdf
Full Article (Word)	WJG-28-5764.docx
Manuscript File	78447_Auto_Edited-LM.docx
Answering Reviewers	78447-Answering reviewers.pdf
Audio Core Tip	78447-Audio core tip.m4a
Biostatistics Review Certificate	78447-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	78447-Conflict-of-interest statement.pdf
Copyright License Agreement	78447-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	78447-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	78447-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	78447-Language certificate.pdf
Supplementary Material	78447-Supplementary material.pdf
Peer-review Report	78447-Peer-review(s).pdf
Scientific Misconduct Check	78447-Bing-Fan JR-2.png
Scientific Editor Work List	78447-Scientific editor work list.pdf
CrossCheck Report	78447-CrossCheck report.pdf
CrossCheck Report	78447-CrossCheck.png