Publication Name	World Journal of Clinical Cases
Manuscript ID	80023
Country	Spain

Received	2022-09-14 10:52
Peer-Review Started	2022-09-14 10:54
To Make the First Decision
Return for Revision	2022-09-26 10:01
Revised	2022-10-06 13:27
Second Decision	2022-10-31 03:19
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-10-31 09:27
Articles in Press	2022-10-31 09:27
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-10-27 22:02
Typeset the Manuscript	2022-11-08 01:55
Publish the Manuscript Online	2022-11-23 09:44

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Prospective Study
Article Title	Predictors of bowel damage in the long-term progression of Crohn’s disease
Manuscript Source	Unsolicited Manuscript
All Author List	Agnes Fernández-Clotet, Julian Panés, Elena Ricart, Jesús Castro-Poceiro, Maria Carme Masamunt, Sonia Rodríguez, Berta Caballol, Ingrid Ordás and Jordi Rimola
ORCID	Author(s) ORCID Number Agnes Fernández-Clotet http://orcid.org/0000-0001-7513-0764 Elena Ricart http://orcid.org/0000-0003-3354-1594 Jesús Castro-Poceiro http://orcid.org/0000-0002-2269-7385 Maria Carme Masamunt http://orcid.org/0000-0001-8736-1623 Sonia Rodríguez http://orcid.org/0000-0002-1257-2757 Berta Caballol http://orcid.org/0000-0002-7921-6730 Ingrid Ordás http://orcid.org/0000-0001-7632-0340 Jordi Rimola http://orcid.org/0000-0002-1814-4198
Funding Agency and Grant Number	Funding Agency Grant Number Helmsley Charitable Trust Grant 2015PG-IBD005
Corresponding Author	Jordi Rimola, MD, PhD, Consultant Physician-Scientist, Department of Radiology, Hospital Clinic, 170 Villarroel, Barcelona 08036, Spain. jrimola@clinic.cat
Key Words	Crohn’s disease; Lémann index; Bowel damage; Inflammatory bowel disease; Magnetic resonance imaging
Core Tip	The aim of the study was to characterize the long-term progression of bowel damage (BD) in patients with Crohn’s disease based on changes in the Lémann index. Predictors of BD progression were a baseline stricturing and fistulizing Crohn’s disease phenotype, ileal location, disease duration of more than 10 years, and a higher Lémann index stricturing score. Strict monitoring of BD-associated lesions during treatment, especially in those patients with a higher baseline Lémann index score, may help clinicians to improve treatment strategies in order to halt BD progression, adapting treatment based on risk factors identified in this study.
Publish Date	2022-11-23 09:44
Citation	Fernández-Clotet A, Panés J, Ricart E, Castro-Poceiro J, Masamunt MC, Rodríguez S, Caballol B, Ordás I, Rimola J. Predictors of bowel damage in the long-term progression of Crohn’s disease. World J Clin Cases 2022; 10(33): 12208-12220
URL	https://www.wjgnet.com/2307-8960/full/v10/i33/12208.htm
DOI	https://dx.doi.org/10.12998/wjcc.v10.i33.12208

Full Article (PDF)	WJCC-10-12208.pdf
Full Article (Word)	WJCC-10-12208.docx
Manuscript File	80023_Auto_Edited-YLC-Filipodia-JLW.docx
Answering Reviewers	80023-Answering reviewers.pdf
Audio Core Tip	80023-Audio core tip.m4a
Biostatistics Review Certificate	80023-Biostatistics statement.pdf
Clinical Trial Registration Statement	80023-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	80023-Conflict-of-interest statement.pdf
Copyright License Agreement	80023-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	80023-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	80023-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	80023-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	80023-Language certificate.pdf
Peer-review Report	80023-Peer-review(s).pdf
Scientific Misconduct Check	80023-Bing-Chen YL-2.png
Scientific Editor Work List	80023-Scientific editor work list.pdf
CrossCheck Report	80023-CrossCheck report.pdf