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Articles Published Processes
3/15/2023 3:41:16 PM | Browse: 215 | Download: 427
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Received |
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2022-09-20 15:21 |
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Peer-Review Started |
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2022-09-20 15:23 |
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To Make the First Decision |
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Return for Revision |
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2022-10-21 21:05 |
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Revised |
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2022-11-30 10:35 |
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Second Decision |
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2023-02-03 03:37 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-02-09 18:28 |
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Articles in Press |
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2023-02-09 18:28 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2023-02-22 07:35 |
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Typeset the Manuscript |
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2023-03-07 13:01 |
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Publish the Manuscript Online |
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2023-03-15 15:41 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Minireviews |
| Article Title |
Role of selenium in type 2 diabetes, insulin resistance and insulin secretion
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Pilar Casanova and Daniel Monleon |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Daniel Monleon, PhD, Professor, Department of Pathology, University of Valencia, 15 Avda Blasco Ibañez, Valencia 46010, Spain. daniel.monleon@uv.es |
| Key Words |
Selenium; Diabetes; Insulin resistance; Metabolism; Antioxidants |
| Core Tip |
In this review we explore the evidence for a role of selenium in insulin resistance and β-cell secretory function. The response to selenium intake has a U-shaped dose-dependent effect so that when it is above the recommended dose, it causes hyperglycemia and hyperinsulinemia which alters not only oxidative stress but also the insulin signaling cascade and lipid and glucose metabolism. Recent findings also suggest that selenoproteins also affect insulin biosynthesis and insulin secretion. Current evidence suggests that the ingestion of selenium supplements should be taken with caution considering the basal levels of selenium in the daily food intake to avoid the development of type 2 diabetes mellitus. |
| Publish Date |
2023-03-15 15:41 |
| Citation |
<p>Casanova P, Monleon D. Role of selenium in type 2 diabetes, insulin resistance and insulin secretion. <i>World J Diabetes</i> 2024; In press</p> |
| URL |
https://www.wjgnet.com/1948-9358/full/v14/i3/147.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v14.i3.147 |
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