Publication Name	World Journal of Diabetes
Manuscript ID	80246
Country	Spain

Received	2022-09-20 15:21
Peer-Review Started	2022-09-20 15:23
To Make the First Decision
Return for Revision	2022-10-21 21:05
Revised	2022-11-30 10:35
Second Decision	2023-02-03 03:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-02-09 18:28
Articles in Press	2023-02-09 18:28
Publication Fee Transferred
Edit the Manuscript by Language Editor	2023-02-22 07:35
Typeset the Manuscript	2023-03-07 13:01
Publish the Manuscript Online	2023-03-15 15:41

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Endocrinology & Metabolism
Manuscript Type	Minireviews
Article Title	Role of selenium in type 2 diabetes, insulin resistance and insulin secretion
Manuscript Source	Invited Manuscript
All Author List	Pilar Casanova and Daniel Monleon
ORCID	Author(s) ORCID Number Daniel Monleon http://orcid.org/0000-0002-4803-1573
Funding Agency and Grant Number
Corresponding Author	Daniel Monleon, PhD, Professor, Department of Pathology, University of Valencia, 15 Avda Blasco Ibañez, Valencia 46010, Spain. daniel.monleon@uv.es
Key Words	Selenium; Diabetes; Insulin resistance; Metabolism; Antioxidants
Core Tip	In this review we explore the evidence for a role of selenium in insulin resistance and β-cell secretory function. The response to selenium intake has a U-shaped dose-dependent effect so that when it is above the recommended dose, it causes hyperglycemia and hyperinsulinemia which alters not only oxidative stress but also the insulin signaling cascade and lipid and glucose metabolism. Recent findings also suggest that selenoproteins also affect insulin biosynthesis and insulin secretion. Current evidence suggests that the ingestion of selenium supplements should be taken with caution considering the basal levels of selenium in the daily food intake to avoid the development of type 2 diabetes mellitus.
Publish Date	2023-03-15 15:41
Citation	Casanova P, Monleon D. Role of selenium in type 2 diabetes, insulin resistance and insulin secretion. World J Diabetes 2023; 14(3): 147-158
URL	https://www.wjgnet.com/1948-9358/full/v14/i3/147.htm
DOI	https://dx.doi.org/10.4239/wjd.v14.i3.147

Full Article (PDF)	WJD-14-147.pdf
Full Article (Word)	WJD-14-147.docx
Manuscript File	80246-Review-Filipodia.docx
Answering Reviewers	80246-Answering reviewers.pdf
Audio Core Tip	80246-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	80246-Conflict-of-interest statement.pdf
Copyright License Agreement	80246-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	80246-Language certificate.pdf
Peer-review Report	80246-Peer-review(s).pdf
Scientific Misconduct Check	80246-Bing-Chen YL-2.png
Scientific Editor Work List	80246-Scientific editor work list.pdf