Publication Name	World Journal of Stem Cells
Manuscript ID	84602
Country	China

Received	2023-03-29 03:52
Peer-Review Started	2023-03-29 03:54
To Make the First Decision
Return for Revision	2023-04-25 05:26
Revised	2023-04-28 08:58
Second Decision	2023-05-24 02:49
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-05-26 00:35
Articles in Press	2023-05-26 00:35
Publication Fee Transferred
Edit the Manuscript by Language Editor	2023-05-23 01:14
Typeset the Manuscript	2023-06-17 12:28
Publish the Manuscript Online	2023-06-26 14:09

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Urology & Nephrology
Manuscript Type	Basic Study
Article Title	Synergism of calycosin and bone marrow-derived mesenchymal stem cells to combat podocyte apoptosis to alleviate adriamycin-induced focal segmental glomerulosclerosis
Manuscript Source	Unsolicited Manuscript
All Author List	Qiong-Dan Hu, Rui-Zhi Tan, Yuan-Xia Zou, Jian-Chun Li, Jun-Ming Fan, Fahsai Kantawong and Li Wang
ORCID	Author(s) ORCID Number Qiong-Dan Hu http://orcid.org/0000-0003-3712-056X Fahsai Kantawong http://orcid.org/0000-0003-0323-3021 Li Wang http://orcid.org/0000-0003-3881-3149
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China (General Program) 82205002 Science and Technology Project of Sichuan Province 2022YFS0621, 21ZDYF0348,2022NSFSC1459 the Luzhou-Southwest Medical University Science and Technology Strategic Cooperation Project 2021LZXNYD-P04 the Southwest Medical University of Affiliated Traditional Medicine Hospital Project 2022-CXTD-03
Corresponding Author	Li Wang, PhD, Professor, Research Center of Integrated Traditional Chinese and Western Medicine, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, No. 182 Chunhui Road, Longmatan District, Luzhou 646000, Sichuan Province, China. wangli120@swmu.edu.cn
Key Words	Calycosin; Mesenchymal stem cells; Focal segmental glomerulosclerosis; Apoptosis; Smad3
Core Tip	Calycosin (CA)-pretreated mesenchymal stem cells (MSCsCA) enhanced the protective effect of MSCs against adriamycin (ADR)-induced podocyte injury in vitro and in vivo by inhibiting apoptosis, accompanied by more reversal of the upregulated expression of p-Smad3 after ADR induction. Smad3 overexpression eliminated the inhibitory effect of MSCsCA on podocyte apoptosis, suggesting that MSCsCA inhibit podocyte apoptosis by targeting p-Smad3. These results broaden our understanding of the potential of MSCs pretreated with herbal extract and provide new theories for possible therapeutic mechanisms for ADR-induced focal segmental glomerulosclerosis.
Publish Date	2023-06-26 14:09
Citation	Hu QD, Tan RZ, Zou YX, Li JC, Fan JM, Kantawong F, Wang L. Synergism of calycosin and bone marrow-derived mesenchymal stem cells to combat podocyte apoptosis to alleviate adriamycin-induced focal segmental glomerulosclerosis. World J Stem Cells 2023; 15(6): 617-631
URL	https://www.wjgnet.com/1948-0210/full/v15/i6/617.htm
DOI	https://dx.doi.org/10.4252/wjsc.v15.i6.617

Full Article (PDF)	WJSC-15-617-with-cover.pdf
Full Article (Word)	WJSC-15-617.docx
The ARRIVE Guidelines	84602-The-ARRIVE-Guidelines-revision.pdf
Manuscript File	84602_Auto_Edited-LM.docx
Answering Reviewers	84602-Answering reviewers.pdf
Audio Core Tip	84602-Audio core tip.m4a
Biostatistics Review Certificate	84602-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	84602-Conflict-of-interest statement.pdf
Copyright License Agreement	84602-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	84602-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	84602-Institutional animal care and use committee statement.PDF
Supplementary Material	84602-Supplementary material.pdf
Peer-review Report	84602-Peer-review(s).pdf
Scientific Misconduct Check	84602-Bing-Chen YL-2.png
Scientific Editor Work List	84602-Scientific editor work list.pdf
CrossCheck Report	84602-CrossCheck report.pdf