Publication Name	World Journal of Gastroenterology
Manuscript ID	90763
Country	Japan

Received	2024-01-09 14:47
Peer-Review Started	2024-01-09 14:47
First Decision by Editorial Office Director	2024-01-17 01:57
Return for Revision	2024-01-17 01:57
Revised	2024-01-30 16:08
Publication Fee Transferred
Second Decision by Editor	2024-03-13 02:47
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2024-03-13 05:52
Articles in Press	2024-03-13 05:52
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-03-28 01:23
Publish the Manuscript Online	2024-04-03 07:21

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Real-world efficacy and safety of tofacitinib treatment in Asian patients with ulcerative colitis
Manuscript Source	Unsolicited Manuscript
All Author List	Kentaro Kojima, Kenji Watanabe, Mikio Kawai, Soichi Yagi, Koji Kaku, Maiko Ikenouchi, Toshiyuki Sato, Koji Kamikozuru, Yoko Yokoyama, Tetsuya Takagawa, Masahito Shimizu and Shinichiro Shinzaki
ORCID	Author(s) ORCID Number Kentaro Kojima http://orcid.org/0000-0002-9000-2426 Kenji Watanabe http://orcid.org/0000-0002-3781-4724 Mikio Kawai http://orcid.org/0000-0001-8004-5927 Soichi Yagi http://orcid.org/0000-0002-2454-2950 Koji Kaku http://orcid.org/0000-0003-0988-8897 Maiko Ikenouchi http://orcid.org/0000-0001-5816-5789 Toshiyuki Sato http://orcid.org/0000-0001-8307-2445 Koji Kamikozuru http://orcid.org/0000-0002-5474-3008 Yoko Yokoyama http://orcid.org/0000-0002-2126-3489 Tetsuya Takagawa http://orcid.org/0000-0001-7335-6962 Masahito Shimizu http://orcid.org/0000-0002-1151-2058 Shinichiro Shinzaki http://orcid.org/0000-0002-7051-618X
Funding Agency and Grant Number
Corresponding Author	Kenji Watanabe, FACG, MD, PhD, Professor, Department of Gastroenterology, Hyogo Medical University, 1-1, Mukogawa-cho, Nishinomiya City, Hyogo Prefecture, Nishinomiya 663-8501, Japan. kenjiw@med.u-toyama.ac.jp
Key Words	Ulcerative colitis; Tofacitinib; Janus kinase inhibitor; Real-world; Biologics
Core Tip	This is a retrospective single-center observational study to investigate the long-term efficacy and safety of tofacitinib (TOF) treatment for ulcerative colitis (UC), including clinical issues. TOF is more effective in low-activity UC patients and its efficacy is not affected by previous treatment with anti-tumor necrosis factor-alpha agents. Most patients in the clinical remission group at week 8 could continue TOF over a long follow-up period. Most relapsed patients responded again after re-increase of TOF and nearly half relapsed after tapering off TOF. Although most patients continue TOF without severe adverse events, careful monitoring for herpes zoster is necessary.
Publish Date	2024-04-03 07:21
Citation	Kojima K, Watanabe K, Kawai M, Yagi S, Kaku K, Ikenouchi M, Sato T, Kamikozuru K, Yokoyama Y, Takagawa T, Shimizu M, Shinzaki S. Real-world efficacy and safety of tofacitinib treatment in Asian patients with ulcerative colitis. World J Gastroenterol 2024; 30(13): 1871-1886
URL	https://www.wjgnet.com/1007-9327/full/v30/i13/1871.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i13.1871

Full Article (PDF)	WJG-30-1871-with-cover.pdf
Manuscript File	90763_Auto_Edited-YJP.docx
Answering Reviewers	90763-Answering reviewers.pdf
Audio Core Tip	90763-Audio core tip.mp3
Biostatistics Review Certificate	90763-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	90763-Conflict-of-interest statement.pdf
Copyright License Agreement	90763-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	90763-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	90763-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	90763-Language certificate.pdf
Peer-review Report	90763-Peer-review(s).pdf
Scientific Misconduct Check	90763-Bing-Fan JR-2.png
Scientific Editor Work List	90763-Scientific editor work list.pdf
CrossCheck Report	90763-CrossCheck report.pdf
CrossCheck Report	90763-CrossCheck.png