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Articles Published Processes
8/28/2014 2:16:00 PM | Browse: 1253 | Download: 1268
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Received |
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2014-01-30 08:51 |
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Peer-Review Started |
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2014-02-08 10:35 |
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To Make the First Decision |
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2014-03-12 16:59 |
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Return for Revision |
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2014-03-19 12:12 |
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Revised |
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2014-03-25 06:14 |
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Second Decision |
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2014-05-29 08:49 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-05-29 09:35 |
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Articles in Press |
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2014-05-29 11:01 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2014-08-25 16:15 |
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Publish the Manuscript Online |
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2014-08-28 14:15 |
| Category |
Chemistry, Medicinal |
| Manuscript Type |
Review |
| Article Title |
Inhibitors of glucose transport and glycolysis as novel anticancer therapeutics
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Yanrong Qian, Xuan Wang and Xiaozhuo Chen |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Heritage College of Osteopathic Medicine of Ohio University |
(to Chen X) |
| Edison Program of State of Ohio |
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| Student Enhancement Award |
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| Graduate Student Senate Original Work Grant |
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| Donald Clippinger Graduate Fellowship from Ohio University |
(to Qian Y) |
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| Corresponding Author |
Xiaozhuo Chen, PhD, Department of Biomedical Sciences, Edison Biotechnology Institute, 109 Konneker Research Laboratories, Ohio University, The Ridges, 172 Watertower Drive, Athens, OH 45701,
United States. chenx@ohio.edu
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| Key Words |
Cancer metabolism; Warburg effect; Glycolytic enzymes; Glucose transporters; Translational research |
| Core Tip |
Reprogramming of metabolism has been recognized at the beginning of 21st century as an emerging hallmark of cancer. The Warburg effect is one of the major focuses in the reprogramming. We cannot fully understand or more effectively treat cancer without a better understanding of cancer metabolism. Targeting cancer metabolism, particularly glucose transport and glycolysis, has been shown to be effective in inhibiting cancer growth. This review summarizes recent progresses in developments of therapeutics inhibiting glucose transporters and glycolytic enzymes, provides key information associated with each inhibitor, discusses their promises and problems as well as future challenges and directions of the basic and translational research of the field |
| Publish Date |
2014-08-28 14:15 |
| Citation |
Qian Y, Wang X, Chen X. Inhibitors of glucose transport and glycolysis as novel anticancer therapeutics. World J Transl Med 2014; 3(2): 37-57 |
| URL |
http://www.wjgnet.com/2220-6132/full/v3/i2/37.htm |
| DOI |
http://dx.doi.org/10.5528/wjtm.v3.i2.37 |
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